Directed Evolution of <i>Candidatus Methanomethylophilus alvus</i> Pyrrolysyl-tRNA Synthetase for the Genetic Incorporation of Two Different Noncanonical Amino Acids in One Protein

2024-8-22

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2024-8-21

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2024-8-21

Development of a Polymersome Blood Ammonia Assay Coupled with a Portable Near-Infrared Fluorometer

2024-7-30

Selagibenzophenone B and Its Derivatives: <b>SelB-1</b>, a Dual Topoisomerase I/II Inhibitor Identified through In Vitro and In Silico Analyses

2024-7-26

Bioproduction Platform to Generate Functionalized Disulfide-Constrained Peptide Analogues

2024-7-12

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2024-6-19

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2024-6-19

Mass Spectrometry-Based Protein Footprinting Defines the Binding Pocket of Crotonylated H3K14 in the PHD1 Domain of BAF45D within the BAF Chromatin Remodeling Complex

2024-6-17

Glycopolymers Prepared by Alternating Ring-Opening Metathesis Polymerization Provide Access to Distinct, Multivalent Structures for the Probing of Biological Activity

2024-5-28

Triblock Glycopolymers with Two 10-mer Blocks of Activating Sugars Enhance the Activation of Acrosomal Exocytosis in Mouse Sperm

2024-4-29

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2024-4-17

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2024-4-17

Enhanced Sequence-Specific DNA Recognition Using Oligodeoxynucleotide-Benzimidazole Conjugates

2024-4-16

Advancing <i>In Situ</i> Analysis of Biomolecular Corona: Opportunities and Challenges in Utilizing Field-Flow Fractionation

2024-3-21

Differences in the Membrane-Binding Properties of Flaviviral Nonstructural 1 (NS1) Protein: Comparative Simulations of Zika and Dengue Virus NS1 Proteins in Explicit Bilayers

2024-3-15

Genetic Targets and Applications of Iron Chelators for Neurodegeneration with Brain Iron Accumulation

2024-3-11

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2024-2-21

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2024-2-21

Effects of Strigolactones on NLRP3 Activation, Nitrosative Stress, and Antioxidant Mox Phenotype: In Vitro and In Silico Evidence

2024-2-19

Seeing Is Believing: Advances in Biological Imaging

2024-1-30

High-Fidelity Assay Based on Turn-Off Fluorescence to Detect the Perturbations of Cellular Proteostasis

2024-1-19

Total Synthesis and Microbiological Evaluation of Leopolic Acid A and Analogues

2024-1-12

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2023-12-20

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2023-12-20

Proteases Involved in Leader Peptide Removal during RiPP Biosynthesis

2023-12-13

Small-Molecule Inhibitors of the m7G-RNA Writer METTL1

2023-12-12

Deciphering the Synthetic and Refolding Strategy of a Cysteine-Rich Domain in the Tumor Necrosis Factor Receptor (TNF-R) for Racemic Crystallography Analysis and <scp>d</scp>-Peptide Ligand Discovery

2023-12-11

Diazirine Photoprobes for the Identification of Vancomycin-Binding Proteins

2023-11-20

The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism

2023-11-15

Conflicting Interfacial Electrostatic Interactions as a Design Principle to Modulate Long-Range Interdomain Communication

2023-11-7

Delineating the Role of GxxxG Motif in Amyloidogenesis: A New Perspective in Targeting Amyloid-Beta Mediated AD Pathogenesis

2023-10-31

Intrinsically Disordered Ku Protein-Derived Cell-Penetrating Peptides

2023-10-31

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2023-10-18

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2023-10-18

The C-Terminal of Na_V1.7 Is Ubiquitinated by NEDD4L

2023-10-13

Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors

2023-9-8

Fusing Peptide Epitopes for Advanced Multiplex Serological Testing for SARS-CoV-2 Antibody Detection

2023-8-30

N4-Substituted Piperazinyl Norfloxacin Derivatives with Broad-Spectrum Activity and Multiple Mechanisms on Gyrase, Topoisomerase IV, and Bacterial Cell Wall Synthesis

2023-8-30

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2023-8-16

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2023-8-16

A Promiscuous rSAM Enzyme Enables Diverse Peptide Cross-linking

2023-8-15

Macrocyclic Peptides Closed by a Thioether–Bipyridyl Unit That Grants Cell Membrane Permeability

2023-8-13

Methimazole, an Effective Neutralizing Agent of the Sulfur Mustard Derivative 2-Chloroethyl Ethyl Sulfide

2023-8-9

Size-Specific Modulation of a Multienzyme Glucosome Assembly during the Cell Cycle

2023-8-8

Functional Diversity in Radiolabeled Nanoceramics and Related Biomaterials for the Multimodal Imaging of Tumors

2023-8-8

Investigating the Roles of Active Site Residues in <i>Mycobacterium tuberculosis</i> Indole-3-glycerol Phosphate Synthase, a Potential Target for Antitubercular Agents

2023-7-26

Chemoenzymatic Synthesis of 3′-Deoxy-3′,4′-didehydro-cytidine triphosphate (ddhCTP)

2023-7-25

Targeting SHP2 with an Active Site Inhibitor Blocks Signaling and Breast Cancer Cell Phenotypes

2023-7-14

Cytochromes P450 Associated with the Biosyntheses of Ribosomally Synthesized and Post-translationally Modified Peptides

2023-7-13