Inhibition of N-Type Calcium Channels by Phenoxyaniline and Sulfonamide Analogues

2024-1-1

Discovery of a new pyrido[2,3-d]pyridazine-2,8-dione derivative as a potential anti-inflammatory agent through COX-1/COX-2 dual inhibition

2024-1-1

Progress on Small-Molecule Inhibitors Targeting PD-L1

2024-1-1

Design and synthesis of chromene-1,2,3-triazole benzene sulfonamide hybrids as potent carbonic anhydrase-IX inhibitors against prostate cancer

2024-1-1

The role of silicon in drug discovery: a review

2024-1-1

Correction: Design and synthesis of eugenol/isoeugenol glycoconjugates and other analogues as antifungal agents against <i>Aspergillus fumigatus</i>

2024-1-1

1,5-disubstituted Tetrazoles as PD-1/PD-L1 Antagonist

2024-1-1

Aptamer AS411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer

2024-1-1

Identification of AdipoRon analogues as novel activators of AMPK for the treatment of type 2 diabetes

2024-1-1

Cornulacin: a new isoflavone from <i>Cornulaca monacantha</i> and its isolation, structure elucidation and cytotoxicity through EGFR-mediated apoptosis

2024-1-1

Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site

2024-1-1

Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management <i>via</i> modulation of the cGAS-STING pathway

2024-1-1

Discovery of aurones bearing two amine functionalities as SHIP2 inhibitors with insulin-sensitizing effect in rat myotubes

2024-1-1

Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents

2024-1-1

Carltonine-derived compounds for targeted butyrylcholinesterase inhibition

2024-1-1

Discovery of Novel SOS1 Inhibitors Using Machine Learning

2024-1-1

Radiosynthesis of [18F]Brequinar for <i>in vivo</i> PET Imaging of <i>h</i>DHODH for Potential Studies of Acute Myeloid Leukemia and Cancers

2024-1-1

Design, Synthesis and Preliminary Biological Evaluation of Rivastigmine-INDY Hybrids as Multitarget Ligands Against Alzheimer's Disease by Targeting Butyrylcholinesterase and DYRK1A/CLK1 Kinases

2024-1-1

Amine-containing Donepezil Analogues as Potent Acetylcholinesterase Inhibitors with Increased Polarity

2024-1-1

Correction: Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents

2024-1-1

Indole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies

2024-1-1

Discovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by a synthetic methodology-based library

2024-1-1

Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents

2024-1-1

Discovery of Novel Positive Allosteric Modulators Targeting GluN1/2A NMDAR as Anti-Stroke Therapeutic Agents

2024-1-1

Deuterium labeling improves the therapeutic index of 3,3′-diselenodipropionic acid as anticancer agent: Insights from redox reactions

2024-1-1

Phosphonodiamidate Prodrugs of Phosphoantigens (ProPAgens) Exhibit Potent Vγ9/Vδ2 T Cell Activation and Eradication of Cancer Cells

2024-1-1

Discovery of Hybrid Glypromate Conjugates with Neuroprotective Activity Against Paraquat-Induced Toxicity

2024-1-1

Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

2024-1-1

Pyrazolopyridine-based kinase inhibitors for anti-cancer targeted therapy

2024-1-1

Photodynamic treatment of <i>Staphylococcus aureus</i> with non-iron hemin analogs in the presence of hydrogen peroxide

2024-1-1

Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure–activity–relationship, and sleep-promoting properties in rats

2024-1-1

N-arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2

2024-1-1

“Seasoning” antimalarial drugs' action: chloroquine bile salts as novel triple-stage antiplasmodial hits

2024-1-1

Design, Synthesis and Biological Evaluation of a Novel PSMA-PI3K Small Molecule Drug Conjugate

2024-1-1

Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

2024-1-1

Front cover

2024-1-1

Synthesis and biological evaluation of new naphthalimide–thiourea derivatives as potent antimicrobial agents active against multidrug-resistant <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i>

2024-1-1

Ebselen analogues with dual human neutrophil elastase (HNE) inhibitory and antiradical activity

2024-1-1

Contents list

2024-1-1

Identification of lysosomotropism using explainable machine learning and morphological profiling cell painting data

2024-1-1

Targeted suppression of oral squamous cell carcinoma by pyrimidine-tethered quinoxaline derivatives

2024-1-1

Hydantoin Derivative Dimers as Broad-spectrum Antimicrobial Agents against ESKAPE Pathogens with Enhanced Killing Rate and Stability

2024-1-1

New pyrazole-pyridazine hybrids as selective COX-2 inhibitors: Design, synthesis, molecular docking, in silico studies and investigation of the anti-inflammatory potential by evaluation of TNF-α, IL-6, PGE-2 and NO in LPS-induced RAW264.7 macrophages

2024-1-1

Synthesis and <i>in vitro</i> evaluation of novel amino-phenylmethylene-imidazolone 5-HT_2A receptor antagonists

2024-1-1

Development of new dehydrocostuslactone derivatives for treatment of atopic dermatitis via inhibition of NF-κB signaling pathway

2024-1-1

Design, synthesis and induced fit docking study of D-glucose-conjugated thioureas containing pyrimidine ring and their inhibition activity against α-amylase, α-glucosidase, DDP-4, PTP1B in treatment for Type 2 diabetes mellitus

2024-1-1

Synthesis of diversely substituted pyridin-2(1H)-ones and in vivo evaluation of their anti-allodynic effect on cutaneous inflammatory mechanical allodynia

2024-1-1

Exploiting spirooxindoles for dual DNA targeting/CDK2 inhibition and simultaneous mitigation of oxidative stress towards selective NSCLC therapy; Synthesis, evaluation, and molecular modelling studies

2024-1-1

Second-generation piperazine derivatives as promising radiation countermeasures

2024-1-1

Phenylstyrylpyrimidine Derivatives as Potential Multipotent Therapeutics for Alzheimer's Disease

2024-1-1