Novel alloxazine analogues: design, synthesis, and antitumour efficacy enhanced by kinase screening, molecular docking, and ADME studies

2024-9-17

Challenging the Biginelli scaffold to surpass the first line antitubercular drugs: <i>Mycobacterium tuberculosis</i> thymidine monophosphate kinase (TMPK <i>mt</i> ) inhibition activity and molecular modelling studies

2024-9-11

Synthesis and in vitro evaluation of benzo[b]thiophene-3-carboxylic acid 1,1-dioxide derivatives as anticancer agents targeting the RhoA/ROCK pathway

2024-9-11

Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases

2024-9-2

Discovery of natural anthraquinones as potent inhibitors against pancreatic lipase: structure-activity relationships and inhibitory mechanism

2024-9-2

Design, synthesis, and biological activity evaluation of dihydromyricetin derivatives against SARS-CoV-2-Omicron virus

2024-8-29

In-cell bioluminescence resonance energy transfer (BRET)-based assay uncovers ceritinib and CA-074 as SARS-CoV-2 papain-like protease inhibitors

2024-8-20

Vitamin B6 inhibits activity of <i>Helicobacter pylori</i> adenylosuccinate synthetase and growth of reference and clinical, antibiotic-resistant <i>H. pylori</i> strains

2024-8-16

Design, synthesis, and biological evaluation of (thio)urea derivatives as potent <i>Escherichia coli β</i> -glucuronidase inhibitors

2024-8-14

Non-small cell lung cancer sensitisation to platinum chemotherapy via new thiazole-triazole hybrids acting as dual T-type CCB/MMP-9 inhibitors

2024-8-14

Crystal structure of dihydroneopterin aldolase from <i>Mycobacterium tuberculosis</i> associated with 8-mercaptoguanine, and development of novel S8-functionalized analogues as inhibitors: Synthesis, enzyme inhibition, <i>in vitro</i> toxicity and antitubercular activity

2024-8-14

Statement of Retraction: Dihydroartemisinin enhances the anti-tumor effect of photodynamic therapy by targeting PKM2-mediated glycolysis in esophageal cancer cell

2024-8-9

Correction

2024-7-29

Design, synthesis, and evaluation of novel stilbene derivatives that degrade acidic nucleoplasmic DNA-binding protein 1 (And1) and synergize with PARP1 inhibitor in NSCLC cells

2024-7-29

Targeting the glutamine-arginine-proline metabolism axis in cancer

2024-7-25

The repertoire of iron superoxide dismutases from <i>Leishmania infantum</i> as targets in the search for therapeutic agents against leishmaniasis

2024-7-22

A comprehensive investigation of the anion inhibition profile of a β-carbonic anhydrase from <i>Acinetobacter baumannii</i> for crafting innovative antimicrobial treatments

2024-7-16

Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting <i>α</i> -amylase, and <i>α</i> -glucosidase: synthesis, molecular docking, and ADMET studies

2024-6-24

Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation

2024-6-21

Novel NO-TZDs and trimethoxychalcone-based DHPMs: design, synthesis, and biological evaluation as potential VEGFR-2 inhibitors

2024-6-21

Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition

2024-6-18

Identification of novel PD-1/PD-L1 small molecule inhibitors: virtual screening, synthesis and <i>in vitro</i> characterisation

2024-6-17

New natural protein tyrosine phosphatase 1B inhibitors from <i>Gynostemma pentaphyllum</i>

2024-6-14

Watermelon: setup and validation of an <i>in silico</i> fragment-based approach

2024-6-12

Effects of thymoquinone and the curcumin analog EF-24 on the activity of the enzyme paraoxonase-1 in human glioblastoma cells U87MG

2024-6-12

Cloning, expression, and purification of an α-carbonic anhydrase from <i>Toxoplasma gondii</i> to unveil its kinetic parameters and anion inhibition profile.

2024-6-7

Exploring of N-phthalimide-linked 1,2,3-triazole analogues with promising ­anti-SARS-CoV-2 activity: synthesis, biological screening, and molecular modelling studies

2024-6-7

Anilino-1,4-naphthoquinones as potent mushroom tyrosinase inhibitors: <i>in vitro</i> and <i>in silico</i> studies

2024-5-30

The activity of pyrazolo[4,3- <i>e</i> ][1,2,4]triazine and pyrazolo[4,3- <i>e</i> ]tetrazolo[1,5- <i>b</i> ][1,2,4]triazine sulphonamide derivatives in monolayer and spheroid breast cancer cell cultures

2024-5-3

Discovery of novel FGFR4 inhibitors through a build-up fragment strategy

2024-4-24

Targeting bacterial growth in biofilm conditions: rational design of novel inhibitors to mitigate clinical and food contamination using QSAR

2024-4-23

Evaluation of the anticancer effects exerted by 5-fluorouracil and heme oxygenase-1 inhibitor hybrids in HTC116 colorectal cancer cells

2024-4-18

Synthesis, carbonic anhydrase inhibition studies and modelling investigations of phthalimide–hydantoin hybrids

2024-4-12

New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies

2024-3-15

Elucidation of critical chemical moieties of metallo-β-lactamase inhibitors and prioritisation of target metallo-β-lactamases

2024-3-15

Discovery of novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors exhibiting antiproliferative activity against non-small cell lung cancer

2024-3-11

Design, synthesis, <i>in vitro</i> and <i>in vivo</i> biological evaluation of pterostilbene derivatives for anti-inflammation therapy

2024-2-29

o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2

2024-2-28

Boronic acid inhibitors of penicillin-binding protein 1b: serine and lysine labelling agents

2024-2-27

Design, synthesis, and evaluation of cyclic C7-bridged monocarbonyl curcumin analogs containing an <i>o</i> -methoxy phenyl group as potential agents against gastric cancer

2024-2-22

Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Alzheimer’s disease

2024-2-16

Development of certain benzylidene coumarin derivatives as anti-prostate cancer agents targeting EGFR and PI3Kβ kinases

2024-2-13

Design, synthesis, molecular modelling and biological evaluation of novel 6-amino-5-cyano-2-thiopyrimidine derivatives as potent anticancer agents against leukemia and apoptotic inducers

2024-2-13

Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors

2024-2-7

Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with <i>in vivo</i> proof

2024-1-30

Discovery of novel and potent CDK8 inhibitors for the treatment of acute myeloid leukaemia

2024-1-23

Computational fragment-based drug design of potential Glo-I inhibitors

2024-1-22

Identification of potential inhibitors against <i>Staphylococcus aureus</i> shikimate dehydrogenase through virtual screening and susceptibility test

2024-1-17

Isolation, structure modification, and anti-rheumatoid arthritis activity of isopimarane-type diterpenoids from <i>Orthosiphon aristatus</i>

2024-1-17

Imparting aromaticity to 2-pyridone derivatives by <i>O</i> -alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis

2024-1-17