Genetics-driven risk predictions leveraging the Mendelian randomization framework

2024-9-27

Evolutionary dynamics of polyadenylation signals and their recognition strategies in protists

2024-9-26

Targeted and complete genomic sequencing of the Major Histocompatibility Complex in haplotypic form of individual heterozygous samples

2024-9-26

Contrasting and combining transcriptome complexity captured by short and long RNA sequencing reads

2024-9-25

Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain

2024-9-25

Designing realistic regulatory DNA with autoregressive language models

2024-9-25

Rapid SARS-COV2 surveillance using clinical, pooled, or wastewater sequence as a sensor for population change

2024-9-25

Systematic identification of interchromosomal interaction networks supports the existence of specialized RNA factories

2024-9-25

<i>AGAP</i>duplicons associate with structural diversity at Chromosome 10q11.22

2024-9-25

Long-read genome sequencing and variant reanalysis increase diagnostic yield in neurodevelopmental disorders

2024-9-19

Full-length RNA transcript sequencing traces brain isoform diversity in house mouse natural populations

2024-9-17

Chromosome-level subgenome-aware de novo assembly of<i>Saccharomyces bayanus</i>provides insight into genome divergence after hybridization

2024-9-17

Long-read RNA sequencing of archival tissues reveals novel genes and transcripts associated with clear cell renal cell carcinoma recurrence and immune evasion

2024-9-16

Measuring X inactivation skew for X-linked diseases with adaptive nanopore sequencing

2024-9-16

Comprehensive identification of genomic and environmental determinants of phenotypic plasticity in maize

2024-9-13

Long-read DNA and cDNA sequencing identify cancer-predisposing deep intronic variation in tumor-suppressor genes

2024-9-13

Enhanced detection of RNA modifications and read mapping with high-accuracy nanopore RNA basecalling models

2024-9-13

A novel approach for in vivo DNA footprinting using short double-stranded cell-free DNA from plasma

2024-9-13

Long-read transcriptome sequencing of CLL and MDS patients uncovers molecular effects of<i>SF3B1</i>mutations

2024-9-13

Evidence for compensatory evolution within pleiotropic regulatory elements

2024-9-10

Differences in activity and stability drive transposable element variation in tropical and temperate maize

2024-9-9

Genetic complexity of killer-cell immunoglobulin-like receptor genes in human pangenome assemblies

2024-9-9

Protein domain embeddings for fast and accurate similarity search

2024-9-5

A Bayesian framework for inferring dynamic intercellular interactions from time-series single-cell data

2024-9-5

Privacy-preserving biological age prediction over federated human methylation data using fully homomorphic encryption

2024-9-5

A best-match approach for gene set analysis in embedding spaces

2024-9-4

Matrix sketching framework for linear mixed models in association studies

2024-9-4

Spatial Cellular Networks from omics data with SpaCeNet

2024-9-4

A scalable adaptive quadratic kernel method for interpretable epistasis analysis in complex traits

2024-8-29

Genome–wide patterns of selection-drift variation strongly associate with organismal traits across the green plant lineage

2024-8-29

Memory-bound<i>k</i>-mer selection for large and evolutionary diverse reference libraries

2024-8-29

Colibactin leads to a bacteria-specific mutation pattern and self-inflicted DNA damage

2024-8-16

Allele specific transcription factor binding across human brain regions offers mechanistic insight into eQTLs

2024-8-16

Widespread natural selection on metabolite levels in humans

2024-8-16

A simple method for finding related sequences by adding probabilities of alternative alignments

2024-8-16

Visualization and analysis of medically relevant tandem repeats in nanopore sequencing of control cohorts with pathSTR

2024-8-15

Benchmarking bulk and single-cell variant calling approaches on Chromium scRNA-seq and scATAC-seq libraries

2024-8-15

A spatiotemporally resolved atlas of mRNA decay in the<i>C. elegans</i>embryo reveals differential regulation of mRNA stability across stages and cell types

2024-8-14

A fast and adaptive detection framework for genome-wide chromatin loop mapping from Hi-C data

2024-8-13

Bayesian inference of sample-specific coexpression networks

2024-8-12

A gene regulatory network–aware graph learning method for cell identity annotation in single-cell RNA-seq data

2024-8-12

The Chinese longsnout catfish genome provides novel insights into the feeding preference and corresponding metabolic strategy of carnivores

2024-8-9

Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data using Decoil

2024-8-7

Secure discovery of genetic relatives across large-scale and distributed genomic datasets

2024-8-7

Independent expansion, selection and hypervariability of the<i>TBC1D3</i>gene family in humans

2024-8-6

The grasshopper genome reveals long-term gene content conservation of the X Chromosome and temporal variation in X Chromosome evolution

2024-8-5

Parameter-efficient fine-tuning on large protein language models improves signal peptide prediction

2024-7-26

Reference-informed prediction of alternative splicing and splicing-altering mutations from sequences

2024-7-26

Accurate assembly of circular RNAs with TERRACE

2024-7-26

Scalable summary statistics-based heritability estimation method with individual genotype level accuracy

2024-7-22