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European Journal of Medicinal Chemistry

短名	Eur. J. Med. Chem.
Journal Impact	5.94
国际分区	CHEMISTRY, MEDICINAL(Q1)
期刊索引	SCI Q1中科院 2 区

ISSN	0223-5234, 1768-3254
h-index	203
国内分区	医学(2区)医学药物化学(1区)
Top期刊	是

《欧洲药物化学杂志》是一本全球性的期刊，专注于药物化学的各个方面。它为原创研究论文提供了一个发表平台，同时也欢迎评论性论文。典型的研究论文通常会报告化合物的有机合成、表征及药理学评估。其他相关主题包括药物设计、定量构效关系（QSAR）、分子建模、药物与受体的相互作用、药物代谢的分子机制、前药合成以及药物靶向。该杂志希望手稿能够展示研究的合理性，提供对化合物设计或机制理解的深刻见解，或阐明研究目标。

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涉及主题	化学生物生物化学遗传学立体化学医学有机化学体外内科学物理药理学核磁共振基因酶组合化学细胞培养
出版信息	出版商: Elsevier Masson s.r.l.，出版周期: Monthly，期刊类型: journal
基本数据	创刊年份: 1974，原创研究文献占比: 92.61%，自引率:10.00%， Gold OA占比: 11.87%
平均审稿周期	网友分享经验：平均4.3个月来源Elsevier官网：平均7.4周
平均录用比例	网友分享经验：较易来源Elsevier官网：32%

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Halogenated retinoid derivatives as dual RARα and RXRα modulators for treating acute promyelocytic leukemia cells

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Development of Peptoid-Based Heteroaryl-Decorated Histone Deacetylase (HDAC) Inhibitors with Dual-Stage Antiplasmodial Activity

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Discovery of Novel BCL6-Targeting PROTACs with Effective Antitumor Activities against DLBCL in Vitro and in Vivo

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Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy

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Extracellular Heat Shock Protein 90 Alpha (eHsp90α)’s Role in Cancer Progression and the Development of Therapeutic Strategies

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Discovery of novel dihydropyrrolidone-thiadiazole compound crosstalk between the YycG/F two-component regulatory pathway and cell membrane homeostasis to combat methicillin-resistant Staphylococcus aureus

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Synthetic Approaches and Clinical Application of Representative Small-Molecule Inhibitors of Phosphodiesterase

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Emerging Therapeutics: The imidazo[1,2-b]pyridazine scaffold as a novel drug candidate for eumycetoma, a neglected tropical disease

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Editorial Board

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Anticancer activity of new water-soluble sulfonated thiosemicarbazone copper(II) complexes targeting disulfide isomerase

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Novel Neuroprotective 5,6-Dihydropyrido[2',1':2,3]imidazo[4,5-c]quinoline Derivatives Acting Through Cholinesterase Inhibition and CB2 Signaling Modulation

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Small Molecule Agents Against Alopecia: Potential Targets and Related Pathways

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Natural Products Targeting Amyloid-β Oligomer Neurotoxicity in Alzheimer's Disease

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Dehydroabietylamine-substituted trifluorobenzene sulfonamide rhodamine B hybrids as anticancer agents overcoming drug resistance

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Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability

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Antitumor activity and transcriptome sequencing (RNA-seq) analyses of hepatocellular carcinoma cells in response to exposure triterpene-nucleoside conjugates

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Quaternized antimicrobial peptide mimics based on harmane as potent anti-MRSA agents by multi-target mechanism covering cell wall, cell membrane and intracellular targets

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Design, synthesis, and evaluation of antitumor activity of 2-arylmethoxy-4-(2-fluoromethyl-biphenyl-3-ylmethoxy) benzylamine derivatives as PD-1/PD-L1 inhibitors

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Overview of PRMT1 Modulators: Inhibitors and Degraders

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Tetrazoles: A multi-potent motif in drug design

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Discovery of novel nitrofuran PROTAC-like compounds as dual inhibitors and degraders targeting STING

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Design, Synthesis, and Molecular Dynamic Simulations of Some Novel Benzo[d]thiazoles with Anti-virulence Activity against Pseudomonas Aeruginosa

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Discovery of the therapeutic potential of PPARδ agonist bearing 1,3,4- thiadiazole in inflammatory disorders

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Design, synthesis, and biological evaluation of diphenyl ether substituted quinazolin-4-amine derivatives as potent EGFRL858R/T790M/C797S inhibitors

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Overview of the PRMT6 Modulators in Cancer Treatment: Current Progress and Emerged Opportunity

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How many organic small molecules might be used to treat COVID-19? From natural products to synthetic agents

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An update on small molecule compounds targeting synthetic lethality for cancer therapy

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Simultaneous Inhibition of FLT3 and HDAC by Novel 6-Ethylpyrazine-2-Carboxamide Derivatives Provides Therapeutic Advantages in Acute Myelocytic Leukemia

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Water-soluble and predictable-release triptolide prodrugs block bleomycin-induced pulmonary fibrosis in mice

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Design, Synthesis, Pharmacological Evaluation, and computational study of benzo[d] isothiazol-based small molecule inhibitors targeting PD-1/PD-L1 interaction.

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European Journal of Medicinal Chemistry

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Halogenated retinoid derivatives as dual RARα and RXRα modulators for treating acute promyelocytic leukemia cells

Development of Peptoid-Based Heteroaryl-Decorated Histone Deacetylase (HDAC) Inhibitors with Dual-Stage Antiplasmodial Activity

Discovery of Novel BCL6-Targeting PROTACs with Effective Antitumor Activities against DLBCL in Vitro and in Vivo

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Extracellular Heat Shock Protein 90 Alpha (eHsp90α)’s Role in Cancer Progression and the Development of Therapeutic Strategies

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Dehydroabietylamine-substituted trifluorobenzene sulfonamide rhodamine B hybrids as anticancer agents overcoming drug resistance

Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability

Synthesis and evaluation of 3,4,5-trisubstituted triazoles as G protein-biased kappa opioid receptor agonists

PROTAC technology: From drug development to probe technology for target deconvolution

Antitumor activity and transcriptome sequencing (RNA-seq) analyses of hepatocellular carcinoma cells in response to exposure triterpene-nucleoside conjugates

Quaternized antimicrobial peptide mimics based on harmane as potent anti-MRSA agents by multi-target mechanism covering cell wall, cell membrane and intracellular targets

Design, synthesis, and evaluation of antitumor activity of 2-arylmethoxy-4-(2-fluoromethyl-biphenyl-3-ylmethoxy) benzylamine derivatives as PD-1/PD-L1 inhibitors

Overview of PRMT1 Modulators: Inhibitors and Degraders

Discovery of 1(2H)-phthalazinone and 1(2H)-isoquinolinone derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors

Tetrazoles: A multi-potent motif in drug design

Discovery of novel nitrofuran PROTAC-like compounds as dual inhibitors and degraders targeting STING

Design, Synthesis, and Molecular Dynamic Simulations of Some Novel Benzo[d]thiazoles with Anti-virulence Activity against Pseudomonas Aeruginosa

Peptides as modulators of FPPS enzyme: a multifaceted evaluation from the design to the mechanism of action

Novel mechanistic insights – A brand new Era for anti-HBV drugs

Drug combinations of camptothecin derivatives promote the antitumor properties

Graphical abstract TOC

Discovery of the therapeutic potential of PPARδ agonist bearing 1,3,4- thiadiazole in inflammatory disorders

Contents continued

Design, synthesis, and biological evaluation of diphenyl ether substituted quinazolin-4-amine derivatives as potent EGFRL858R/T790M/C797S inhibitors

Overview of the PRMT6 Modulators in Cancer Treatment: Current Progress and Emerged Opportunity

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How many organic small molecules might be used to treat COVID-19? From natural products to synthetic agents

An update on small molecule compounds targeting synthetic lethality for cancer therapy

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Simultaneous Inhibition of FLT3 and HDAC by Novel 6-Ethylpyrazine-2-Carboxamide Derivatives Provides Therapeutic Advantages in Acute Myelocytic Leukemia

Water-soluble and predictable-release triptolide prodrugs block bleomycin-induced pulmonary fibrosis in mice

Self-Assembly of a Ruthenium-Based cGAS-STING Photoactivator for Carrier-Free Cancer Immunotherapy

New Insights into Butyrylcholinesterase: Pharmaceutical Applications, Selective Inhibitors and Multitarget-Directed Ligands

Novel carbazole-oxadiazole derivatives as anti-α-glucosidase and anti-α-amylase agents: Design, synthesis, molecular docking, and biological evaluation

An overview of RAF kinases and their inhibitors (2019-2023)

Design, Synthesis, Pharmacological Evaluation, and computational study of benzo[d] isothiazol-based small molecule inhibitors targeting PD-1/PD-L1 interaction.

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