CURRENT MEDICAL SCIENCE 为医学科学领域的同行评议论文提供论坛，以促进中国研究人员和医生与外国同行之间的学术交流。期刊涵盖生理学、生物化学、分子生物学、药理学、病理学和病理生理学等生物医学学科和外科、内科、妇产科、儿科、耳鼻喉科等临床研究学科。 MEDICAL SCIENCE 以英文为主，极少数论文为德文，以向其德国创始人致敬。本刊是中国中部地区教育机构主办的唯一西文医学期刊。

Current Medical Science is a peer-reviewed journal that provides a forum for papers in the field of medical science, aimed at promoting academic exchange between Chinese researchers and physicians and their international counterparts. The journal covers biomedical disciplines such as physiology, biochemistry, molecular biology, pharmacology, pathology, and pathophysiology, as well as clinical research fields including surgery, internal medicine, obstetrics and gynecology, pediatrics, and otorhinolaryngology. The journal primarily publishes in English, with a very limited number of papers in German, in honor of its German founder. It is the only Western medical journal published by educational institutions in Central China.

《Current Medical Science》是一个为医学科学领域的同行评审论文提供论坛的期刊，旨在促进中国研究人员和医生与国际同行之间的学术交流。该期刊涵盖生理学、生物化学、分子生物学、药理学、病理学和病理生理学等生物医学学科，以及外科、内科、妇产科、儿科、耳鼻喉科等临床研究领域。期刊主要以英文发表，极少数论文为德文，以向其德国创始人致敬。本刊是中国中部地区教育机构主办的唯一西文医学期刊。

Current Medical Science

Developing the methodologies that allow for safe and effective delivery of therapeutic drugs to target sites is a very important research area in cancer therapy. In this study, polyethylene glycol (PEG)-coated magnetic polymeric liposome (MPL) nanoparticles (NPs) assembled from octadecyl quaternized carboxymethyl chitosan (OQC), PEGylated OQC, cholesterol, and magnetic NPs, and functionalized with epithelial growth factor receptor (EGFR) peptide, were successfully prepared for in-vivo liver targeting. The two-step liver targeting strategy, based on both magnetic force and EGFR peptide conjugation, was evaluated in a subcutaneous hepatocellular carcinoma model of nude mouse. The results showed that EGFR-conjugated MPLs not only accumulated in the liver by magnetic force, but could also diffuse into tumor cells as a result of EGFR targeting. In addition, paclitaxel (PTX) was incorporated into small EGFR-conjugated MPLs (102.0±0.7 nm), resulting in spherical particles with high drug encapsulation efficiency (>90%). The use of the magnetic targeting for enhancing the transport of PTX-loaded EGFR-conjugated MPLs to the tumor site was further confirmed by detecting PTX levels. In conclusion, PTX-loaded EGFR-conjugated MPLs could potentially be used as an effective drug delivery system for targeted liver cancer therapy.

Zhen-Lv Lin

Jian Ding

Guo-Ping Sun

Dan Li

Shan-Shan He

Xiao-Fei Liang

Xun-Ru Huang

Jie Xie

Current medical science

Curr Med Sci

Application of Paclitaxel-loaded EGFR Peptide-conjugated Magnetic Polymeric Liposomes for Liver Cancer Therapy.

载紫杉醇的EGFR肽偶联磁性聚合物脂质体在肝癌治疗中的应用。

In this study, the response of Dectin-1 on macrophages to Fusarium solani (F. solani) and the expression patterns of Dectin-1 in experimentally F. solani-induced keratomycosis were investigated. Peritoneal macrophages isolated after intraperitoneal injection of sodium thioglycollate were co-cultured with laminarin and spores of F. solani for 12 h. The expression levels of Dectin-1 and CARD9 were detected by immunofluorescence and real-time quantitative polymerase chain reaction. A mouse model of fungal keratitis was established by substromal inoculation with spores of F. solani. Corneal lesions and inflammatory responses were observed by slit-lamp and histopathology at 1, 2, 3, 5, and 7 day(s) after infection. Dectin-1 expression was significantly upregulated on macrophages stimulated by spores of F. solani. Dectin-1 was not detected in normal corneas of C57BL/6 mice, but detected in infected corneas from the first day after inoculation, with high mRNA levels observed on days 2 and 3. CARD9, a key transducer of Dectin-1 signaling, was also upregulated in infected corneas. In conclusion, Dectin-1 is an important recognition receptor in F. solani-induced keratitis, but the molecular mechanisms warrant further investigation.

Ling-Juan Xu

Li-Xin Xie

Fusarium solani Activates Dectin-1 in Experimentally Induced Keratomycosis.

镰刀菌属激活实验性诱导角膜真菌病中的Dectin-1。

Kai-kai Guo

Chang-ya Liu

Gao-hui Li

Jian-ping Xiang

Xiao-chang Leng

Yi-ke Cai

Xue-bin Hu

Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms

前循环分叉与侧壁动脉瘤形态学和血流动力学参数的差异与相关性

Respiratory syncytial virus (RSV) infection is the primary cause of respiratory disease in infants. The formalin-inactivated RSV (FI-RSV) vaccine resulted in an enhanced respiratory disease (ERD) in infants upon natural RSV infection, which is a major obstacle for development of safe and efficacious vaccines. Excessive and uncontrolled Th immune responses could be involved in the ERD. Agonists of TLRs are used as adjuvants to guide the type of immune response induced by vaccines. We evaluated the impact of lipopolysaccharide (LPS), the agonist of TLR4, on ERD as the adjuvant of FI-RSV. The results showed that LPS remarkably inhibited FI-RSV-enhanced lung inflammation, mucus production, airway inflammatory cell infiltration, and inflammatory cytokines following RSV challenge. Interestingly, LPS inhibited both Th2 and Th17 type cytokines in lungs of FI-RSV-immunized mice following RSV challenge, without an increase in the Th1 type cytokines, suggesting a controlled immune response. In contrast, Pam3Cys and Poly(I:C), the agonist of TLR1/2 or TLR3, partly inhibited FI-RSV-enhanced lung inflammation. Pam3Cys inhibited Th17 type cytokine IL-17, but promoted both Th1 and Th2 type cytokines. Poly(I:C) inhibited Th2 and Th17 type cytokines, but promoted Th1 type cytokines. In addition, LPS promoted IgG and IgG2a antibody production, which might provide protection from RSV challenge. These results suggest that LPS inhibits ERD without impairment in antibody production and protection, and the mechanism appears to be related with regulation of Th responses induced by FI-RSV.

Wei Yin

Hong-Yong Li

Bo-Yang Zheng

Yu-Qing Deng

Wen-Jian Li

Ying Liu

Rui-Hong Zeng

Lipopolysaccharide Inhibits FI-RSV Vaccine-enhanced Inflammation Through Regulating Th Responses.

脂多糖通过调节Th反应抑制FI-RSV疫苗增强的炎症。

The activation state of microglia is known to occupy a central position in the pathophysiological process of cerebral inflammation. Autophagy is a catabolic process responsible for maintaining cellular homeostasis. In recent years, autophagy has been demonstrated to play an important role in neuroinflammation. Resolvin D1 (RvD1) is a promising therapeutic mediator that has been shown to exert substantial anti-inflammatory and proresolving activities. However, whether RvD1-mediated resolution of inflammation in microglia is related to autophagy regulation needs further investigation. The present study aimed to explore the effect of RvD1 on microglial autophagy and its corresponding pathways.

Shang-Wen Pan

Li-Sha Hu

Han Wang

Rui-Ting Li

Ya-Jun He

You Shang

Zhong-Liang Dai

Li-Xin Chen

Wei Xiong

Resolvin D1 Induces mTOR-independent and ATG5-dependent Autophagy in BV-2 Microglial Cells.

Resolvin D1 在BV-2小胶质细胞中诱导mTOR非依赖性和ATG5依赖性的自噬。

Myocardial ischemia-reperfusion (I/R) injury is associated with a significant reduction in the mitochondrial membrane potential (MMP, ΔΨm). Fluorescence-based assays are effective for labelling active mitochondria in living cells; their application in heart tissue, however, represents a challenge because of a low yield of viable cardiomyocytes after cardiac perfusion. This study aimed to examine a novel method for detecting the changes in the MMP of mouse heart tissue following I/R injury.

Chao Yin

Chen-xing Huang

Le Pan

Ke-jia Jin

Ying Wang

Meng-ying Cao

Hong Lin

Pan Gao

Na Li

Hui Gong

Yun-zeng Zou

A Novel Method for Mitochondrial Membrane Potential Detection in Heart Tissue Following Ischemia-reperfusion in Mice

小鼠心肌缺血-再灌注后线粒体膜电位检测的新方法

Imbalances in liver lipid metabolism and inflammatory reactions driven by oxidized lipid deposition in blood vessels constitute the core of atherosclerosis. Insufficient degradation of cholesterol in the liver promotes oxidative modification of lipid particles and their deposition on the blood vessel wall in the peripheral circulation. The blood vessel wall engulfs and processes oxidized low-density lipoprotein (Ox-LDL) as foreign matter through pattern recognition receptors, ultimately forming lipid-encapsulated plaques. Among them, endothelial cell oxidized low density lipoprotein receptor 1 (LOX1) phagocytosis is an important link in initiating and promoting this mechanism, and hepatocytes, which are the core of lipid metabolism, are unable to process oxidized lipid particles because of the lack of receptors for the uptake of Ox-LDL. The objective of this study was to investigate whether continuous clearance of Ox-LDL through the liver metabolic pathway could provide better protection against statins therapy.

Wen-ping Zhou

Xin-rui Fan

Song-hai Li

Zhuang-lin Zeng

Yu-miao Wei

Statins Combined with AAV8-TBG-LOX-1 Reduce the Vascular Lipid-driven Inflammatory Response and Inhibit Atherosclerosis

他汀联合AAV8-TBG-LOX-1降低血管脂质驱动炎症反应并抑制动脉粥样硬化

To investigate the distribution characteristics of common bacteria and changes in antimicrobial resistance in intensive care unit (ICU) patients in 58 hospitals in Hubei Province from 2020-2023.

Sui Gao

Cui Jian

Trends in Bacterial Distribution and Antimicrobial Resistance in Intensive Care Units of Hubei Province, China: A Four-year Surveillance Study (2020–2023)

湖北省重症监护病房细菌分布及抗菌药物耐药性趋势：一项四年监测研究（2020-2023）

Jianpi huoxue decoction (JHD), a Chinese herbal formula, is commonly used for treating alcohol-associated liver disease (ALD). This study aimed to investigate the mechanism by which JHD affects intestinal barrier function in ALD rats.

Xin Wang

Dong-sheng Yao

Lin Xu

Dong-ming Yan

Yu Zhao

Jing-hua Peng

Qi-lin Fu

Yi-yang Hu

Qin Feng

Jianpi Huoxue Decoction Ameliorates Alcohol-associated Liver Disease by Improving Intestinal Barrier Function in Rats

健脾化瘀汤通过改善大鼠肠道屏障功能缓解酒精性肝病

Human adipose-derived stem cells (ASCs) have shown considerable potential for tissue regeneration. FK506 binding protein (FKBP) 5 is a cochaperone of several proteins. The purpose of this work was to explore the function of FKBP5 in ASC osteogenesis.

Xiao-yu Tian

Biao Zhu

Wen-can Fang

Xiang-bin Zhou

Ning Wu

Hong Li

Ning Wen

Jin Li

FKBP5 Regulates the Osteogenesis of Human Adipose-derived Mesenchymal Stem Cells

FKBP5调控人脂肪源性间充质干细胞的成骨分化

Abbreviation	Curr. Med. Sci.
Journal Impact	1.88
Quartiles(Global)	MEDICINE, RESEARCH & EXPERIMENTAL(Q3)

ISSN	2096-5230, 2523-899X
h-index	39

Publication Information	Publisher: Huazhong University of Science and Technology，Publishing cycle: 6 issues per year，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2018，Proportion of original research papers: 96.53%，Self Citation Rate:5.00%， Gold OA Rate: 10.99%

Current Medical Science

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