NUCLEOSIDES、NUCLEOTIDES & NUCLEIC ACIDS 发表研究文章、简短通知以及对相关主题的简明、批判性评论，重点关注核苷、核苷酸和核酸的化学和生物学。这本全包期刊包含实验细节，强调合成、生物活性、新的和改进的合成方法，以及与新化合物相关的重要观察。

The journal "Nucleosides, Nucleotides and Nucleic Acids" publishes research articles, brief communications, and concise critical reviews on related topics, focusing on the chemistry and biology of nucleosides, nucleotides, and nucleic acids. This comprehensive journal includes experimental details, emphasizing synthesis, bioactivity, new and improved synthetic methods, and significant observations related to new compounds.

《Nucleosides, Nucleotides and Nucleic Acids》期刊发表研究文章、简短通知以及对相关主题的简明、批判性评论，重点关注核苷、核苷酸和核酸的化学与生物学。这本综合性期刊包含实验细节，强调合成、生物活性、新的和改进的合成方法，以及与新化合物相关的重要观察。

Nucleosides, Nucleotides and Nucleic Acids

Abstract It is hypothesized that hyperuricemia in males is caused by androgen-induced urate reabsorptive transport system in the kidney. The expression of urate transporter 1 (Urat1), sodium-coupled monocarboxylate transporter 1 (Smct1) and glucose transporter 9 (Glut9) were investigated in orchiectomized mice with or without testosterone replacement. Testosterone enhanced mRNA and protein levels of Smct1 while those of Glut9 were attenuated. Although the mRNA level of Urat1 was enhanced by testosterone, the corresponding levels of Urat1 protein remained unaffected. Thus, the induction of Smct1 by testosterone is a candidate mechanism underlying hyperuricemia in males. Keywords: Uratetransporterkidneytestosterone Acknowledgments This study was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology (Grant 17590843) and the Uehara Memorial Foundation.

M. Hosoyamada

Y. Takiue

T. Shibasaki

H. Saito

Nucleosides Nucleotides & Nucleic Acids

The Effect of Testosterone Upon the Urate Reabsorptive Transport System in Mouse Kidney

睾酮对小鼠肾脏尿酸重吸收转运系统的影响

Abstract Condensation of cyanoacetamide and cyanothioacetamide with the sodium salts of a-(hydroxymethylene)alkanones afforded the pyridine-2(1H)-ones and their corresponding thiones 3. Compounds 3 served as a key intermediates for the synthesis of N-glycosylated pyridines.

Badria A. Hussain

Adel M. Attia

Galal E. H. Elgemeie

Nucleosides and Nucleotides

Synthesis ofN-Glycosylated Pyridiines as New Antimetabolite Agents

合成N-糖基化吡啶作为新型抗代谢物药物

Leukemia is a cancer affecting the hematopoietic system with an unclear pathogenesis. Recent studies suggest a correlation between several long non-coding RNAs (lncRNAs) and leukemia development. This study focuses on the potential link between

Paria Farhadian

Mohammad Javad Mokhtari

Association between genetic variants (rs2839698, and rs217727) in lncRNA H19 and Acute lymphoblastic leukemia susceptibility: a case-control study in the Iranian population

lncRNA H19基因变异（rs2839698和rs217727）与急性淋巴细胞白血病易感性的关联：伊朗人群的病例对照研究

Varkud satellite ribozyme (VS ribozyme) is a class of catalytic RNA with self-cleavage activity. The wild-type VS ribozyme has structural modularity with a relatively large catalytic module (H2-H6 elements) and a small substrate module (H1 element). The two modules can be dissected physically, and the substrate H1 RNA is recognized and then cleaved by the rest of the parent ribozyme serving as catalytic RNA. We characterized the catalytic properties of a bimolecular VS ribozyme developed and employed for an in-droplet evolution experiment of the VS ribozyme. We examined the effects of polyamines and several divalent metal ions. The results obtained in this study would be useful for the optimization of laboratory evolution of the VS ribozyme.

Yuki Miyzaki

Ryu Nakane

Shogo Tanishi

Shigeyoshi Matsumura

Yoshiya Ikawa

Catalytic cleave of an RNA substrate that bypasses the reorganization of its secondary structure during substrate recognition by a trans -acting VS ribozyme

通过trans-作用VS核酶在底物识别过程中绕过其二级结构重排的RNA底物催化切割

Osteoporosis is a common age-related skeletal disease, characterized by changes in the microarchitectural structure of bone tissue and decreased bone mass, especially affecting postmenopausal women. Genetic and environmental factors affecting bone metabolism play a role in the development of osteoporosis. Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in the conversion of homocysteine to methionine. Genetic variations in the MTHFR gene lead to impaired function or inactivation of this enzyme. A decrease in MTHFR enzyme activity and an increase in homocysteine levels affect bone metabolism. In this study, we aimed to investigate the relationship between C677T and A1298C polymorphisms and osteoporosis in Turkish postmenopausal women. DNA samples were extracted from 200 volunteers. The PCR-RFLP technique was used to identify the MTHFR gene polymorphisms C677T and A1298C. The statistical significance of the analysis's results was assessed. C677T genotype and allele frequency distributions were not statistically different between postmenopausal osteoporosis and healthy control groups (

Fulya Doğaner

Ahu Soyocak

Didem Turgut Coşan

Merih Özgen

Funda Berkan

Fezan Şahin Mutlu

İrfan Değirmenci

Hasan Veysi Güneş

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in Turkish postmenopausal women with osteoporosis

土耳其绝经后骨质疏松妇女中亚甲基四氢叶酸还原酶（MTHFR）C677T和A1298C多态性研究

Background: Recent research has revealed a significant association between Anillin (ANLN) and miR-374a‑5p with the progression of tumors. Additionally, bioinformatics analysis indicated an inverse relationship in transcript expression levels between ANLN and miR-374a-5p. However, the specific mechanisms driving the miR-374a-5p/ANLN signaling axis in oral squamous cell carcinoma (OSCC) have not been thoroughly explored. Methods: ANLN and miR-374a‑5p expression were evaluated within OSCC cell lines and tissues by RT-qPCR. Using bioinformatics databases, it has been demonstrated that the ANLN gene could be a target of miR-374a-5p. MiR-374a‑5p and ANLN correlation could be assessed via the dual-luciferase reporter assay and western blotting techniques. Functional studies were employed to investigate the behavioral patterns of miR-374a‑5p within OSCC cells. Results: miR-374a‑5p expression could be remarkably downregulated within both OSCC tissues and cells, coinciding with high ANLN expression. ANLN was a specific target gene for miR-374a‑5p by luciferase function assay. The expression of miR-374a‑5p could serve as a diagnostic biomarker and independently predict a poor prognosis in patients with OSCC, and the counteractive effect of upregulating miR-374a‑5p was observed on the proliferative, migratory, and invasive capabilities of OSCC cells. Conclusions: The findings suggest that the miR-374a‑5p/ANLN signaling axis potentially modulates the advancement of OSCC, and miR-374a‑5p may serve as potential therapeutic targets of oral cancer.

Shu Wu

Danping Li

Peipei Han

Limei Li

Jun Zhao

Haishan Zhang

Xiaohui Zhou

Ping Li

Yingxi Mo

MicroRNA‑374a‑5p/ANLN axis promotes malignant progression of Oral squamous cell carcinoma

MicroRNA‑374a‑5p/ANLN轴促进口腔鳞状细胞癌的恶性进展

The development of alternative anticancer agents with minimal side effects has become more critical due to the rising recurrence of mammalian malignancies and the severe side effects of chemotherapeutic treatments. Kinases are an essential target for neostatic impact as they play an important role in the modulation of growth factor signalling. Our work aims to screen novel nine-series of thiazole-based aminopyrimidines and sulphaminopyrimidines against the enzymes mitochondrial thymidine kinase 2, deoxyguanosine kinase (2OCP), deoxycytidine kinase (2QRN) and thymidylate kinase (1E2Q) by molecular docking, synthesise and to study their in vitro inhibitory studies. The synthesised compounds were characterised by Infrared, Nuclear magnetic resonance and Mass spectroscopy. In silico studies, compound 4c stands out among the series, with a reported docking score ranging from −6 to −8 Kcal/mol against all the analogue kinases. The in vitro cytotoxicity assay against human small-cell lung carcinoma (A-549) has shown that 5c (IC50 = 53.9 µM) has an excellent cytotoxic effect over 4c (IC50= 68.68 µM). The reason might be the presence of the benzene sulphonamide group, which enhances their anticancer action. To conclude, the compounds 4c and 5c were found to be potent inhibitors of the deoxynucleoside kinases. In vivo studies must further verify these to prove their potent neostatic effect.

Jainey P. James

Mariyam Jouhara B. M.

Sneh Priya

Divya Jyothi

Rajalakshimi Vasudevan

Homology modelling, molecular docking studies and synthesis of aminopyrimidines as inhibitors for deoxynucleoside kinase analogues in cancer chemoprevention

同源建模、分子对接研究和氨基嘧啶的合成作为癌症化学预防中脱氧核苷酸激酶类似物的抑制剂

Abbreviation	Nucleosides. Nucleotides. Nucleic. Acids.
Journal Impact	0.94
Quartiles(Global)	BIOCHEMISTRY & MOLECULAR BIOLOGY(Q4)

ISSN	0732-8311, 1525-7770, 1532-2335
h-index	53

Publication Information	Publisher: Taylor and Francis Ltd.，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2000，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

Nucleosides, Nucleotides and Nucleic Acids

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The Effect of Testosterone Upon the Urate Reabsorptive Transport System in Mouse Kidney

Synthesis ofN-Glycosylated Pyridiines as New Antimetabolite Agents

Association between genetic variants (rs2839698, and rs217727) in lncRNA H19 and Acute lymphoblastic leukemia susceptibility: a case-control study in the Iranian population

Catalytic cleave of an RNA substrate that bypasses the reorganization of its secondary structure during substrate recognition by a trans -acting VS ribozyme

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in Turkish postmenopausal women with osteoporosis

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in Turkish postmenopausal women with osteoporosis

Association between genetic variants (rs2839698, and rs217727) in lncRNA H19 and Acute lymphoblastic leukemia susceptibility: a case-control study in the Iranian population

Catalytic cleave of an RNA substrate that bypasses the reorganization of its secondary structure during substrate recognition by a trans -acting VS ribozyme

MicroRNA‑374a‑5p/ANLN axis promotes malignant progression of Oral squamous cell carcinoma

Homology modelling, molecular docking studies and synthesis of aminopyrimidines as inhibitors for deoxynucleoside kinase analogues in cancer chemoprevention