Japanese Journal of Chemotherapy

Shigeru Kohno

Akira Watanabe

Toshiharu Matsushima

Nihon Kagaku Ryōhō Gakkai zasshi/Nihon Kagaku Ryoho Gakkai zasshi

Nationwide multicenter survey on the pathophysiology of hospital-acquired pneumonia and the use of first-line antibiotics in Japan: Evaluation of clinical position of meropenem in the initial therapy of hospital-acquired pneumonia

日本医院获得性肺炎病理生理学及一线抗生素使用情况的全国多中心调查：评估美罗培南在医院获得性肺炎初始治疗中的临床地位

Fumiyuki Sugime

Shigekazu Sugino

Masanori Yamauchi

Sohshi Iwasaki

Masayasu Nakayama

Noriaki Kanaya

Akiyoshi Namiki

A case of intraoperative anaphylactic shock treated based on a guideline for anaphylactic reaction associated with antibiotics

基于抗生素相关过敏反应指南治疗手术中过敏性休克一例

Katsunao Niitsuma

Hiroaki Takeda

Nobuki Aoki

Penetration into sputum study of garenoxacin in patients with secondary infection of chronic respiratory disease

慢性呼吸系统疾病继发感染患者加雷沙星痰液渗透研究

Satoshi Iwata

Hiromi Kumon

Yoshihito Niki

Mitsuo Kaku

Kouichi Wada

Keisuke Sunakawa

Hiroshige Mikamo

Yoshio Takesue

Naomasa Gotoh

Kouichi Monden

Survey on once-daily therapy with ceftriaxone for pediatric bacterial infections

儿童细菌感染每日一次头孢曲松治疗的调查

Hiroko Kanda

Yuichi Kurosaka

Katsuko Fujikawa

Megumi Chiba

Shinichiro Yamachika

Ryo Okumura

Yoshinori Kashimoto

Saori Uoyama

Kazuki Hoshino

Mayumi Tanaka

Tsuyoshi Otani

In vitro and in vivo antibacterial activity of sitafloxacin

体外和体内西他沙星的抗菌活性

The emergence of novel, as well as re-emergence of serious respiratory viral diseases in the current decade is of particular concern Fatal acute respiratory distress syndrome (ARDS) with rapid deterioration of vital organ functions has been observed in some patients infected with the highly pathogenic influenza virus strains, severe acute respiratory syndrome coronavirus (SARS-CoV), and middle east respiratory syndrome corona virus (MERS-CoV) The common manifestations of virus-induced fatal ARDS are cytokine storm and activation of monocytes/macrophages, characterized as secondary hemophagocytic syndrome (HPS)/hemophagocytic lymphohistiocytosis (HLH) However, infection-induced HPS/HLH is likely to be under-recognized, which could contribute to the serious progression and high mortality Since there are no established criteria for the diagnosis of infection-induced HPS/HLH, early recognition is crucial for any reasonable attempt at curative treatment Etoposide (ET), a cytotoxic agent, and corticosteroids (CS), with their strong anti-inflammatory activities, have been used to treat other diseases with similar pathophysiology, namely, cytokine-activated macrophages and hemophagocytic activity, but it remains unknown whether these agents can also influence the clinical outcomes in patients with fatal ARDS and secondary HPS/HLH We established an animal model of fatal ARDS, with severe lung injury, hypercytokinemia, and hemophagocytosis Using this animal model, we demonstrated that combined therapy with ET plus CS, targeting monocytes/macrophages, but not inflammatory cytokines, had the potential to attenuate the severity of fatal ARDS Specific treatment against HPS/HLH, including combined ET plus CS therapy, could be considered in patients with fatal ARDS complicated by secondary HPS/HLH To improve the outcomes in patients with infection-induced fatal ARDS, clinical and basic science studies are needed in the future to elucidate the mechanisms underlying the pathogenesis of ARDS and identify new treatment targets

Tetsuji Aoyagi

Yukio Sato

Kazuyoshi Kawakami

Targeted therapy against macrophages/monocytes in fatal acute respiratory distress syndrome

针对致死性急性呼吸窘迫综合征中巨噬细胞/单核细胞的靶向治疗

针对致命性急性呼吸窘迫综合征中巨噬细胞/单核细胞的靶向治疗

ISSN	1340-7007, 1884-5886
h-index	13

Publication Information	Publisher: Japanese Society of Chemotherapy，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1995，Proportion of original research papers: 0.00%，Self Citation Rate:N.A.， Gold OA Rate: 0.00%

Japanese Journal of Chemotherapy

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Nationwide multicenter survey on the pathophysiology of hospital-acquired pneumonia and the use of first-line antibiotics in Japan: Evaluation of clinical position of meropenem in the initial therapy of hospital-acquired pneumonia

A case of intraoperative anaphylactic shock treated based on a guideline for anaphylactic reaction associated with antibiotics

Penetration into sputum study of garenoxacin in patients with secondary infection of chronic respiratory disease

Survey on once-daily therapy with ceftriaxone for pediatric bacterial infections

In vitro and in vivo antibacterial activity of sitafloxacin

Targeted therapy against macrophages/monocytes in fatal acute respiratory distress syndrome

Targeted therapy against macrophages/monocytes in fatal acute respiratory distress syndrome

Targeted therapy against macrophages/monocytes in fatal acute respiratory distress syndrome

Targeted therapy against macrophages/monocytes in fatal acute respiratory distress syndrome

Targeted therapy against macrophages/monocytes in fatal acute respiratory distress syndrome