TRENDS IN CELL BIOLOGY 是分子和细胞生物学领域领先的评论期刊之一。每月发表的评论文章监控当前细胞生物学研究的广度和深度，及时报告新的发展，整合方法、学科和原则。所有文章均由顶尖科学家委托，然后经过严格的同行评审，确保平衡和准确性。除了评论之外，TRENDS IN CELL BIOLOGY 还发表意见文章，这些文章跟踪趋势并提供创新想法，以洞察新发展的影响并提出未来方向。

Trends in Cell Biology is one of the leading review journals in the field of molecular and cell biology. The journal publishes monthly review articles that monitor the breadth and depth of current research in cell biology, reporting new developments in a timely manner and integrating methods, disciplines, and principles. All articles are commissioned by top scientists and undergo rigorous peer review to ensure balance and accuracy. In addition to review articles, Trends in Cell Biology also publishes opinion pieces that track trends and provide innovative ideas to insightfully assess the impact of new developments and suggest future directions.

《Trends in Cell Biology》是分子和细胞生物学领域领先的评论期刊之一。该期刊每月发表的评论文章监测当前细胞生物学研究的广度和深度，及时报道新的发展，整合方法、学科和原则。所有文章均由顶尖科学家委托，并经过严格的同行评审，以确保内容的平衡和准确性。除了评论文章外，《Trends in Cell Biology》还发表意见文章，这些文章跟踪趋势并提供创新想法，以洞察新发展的影响并提出未来的研究方向。

Trends in Cell Biology

Most current research in cell biology uses just a handful of model systems including yeast, Arabidopsis, Drosophila, Caenorhabditis elegans, zebrafish, mouse, and cultured mammalian cells. And for good reason - for many biological questions, the best system for the question is likely to be found among these models. However, in some cases, and particularly as the questions that engage scientists broaden, the best system for a question may be a little-studied organism. Modern research tools are facilitating a renaissance for unusual and interesting organisms as emerging model systems. As a result, we predict that an ever-expanding breadth of model systems may be a hallmark of future cell biology.

Bob Goldstein

Nicole King

Trends in cell biology

Trends Cell Biol

The Future of Cell Biology: Emerging Model Organisms.

Ferroptosis is an iron-dependent lethal mechanism that can be activated in disease and is a proposed target for cancer therapy. Ferroptosis is defined by the overwhelming accumulation of membrane lipid peroxides. Ferroptotic lipid peroxidation is initiated on internal membranes and then appears at the plasma membrane, triggering lethal ion imbalances and membrane permeabilization. Sensitivity to ferroptosis is governed by the levels of peroxidizable polyunsaturated lipids and associated lipid metabolic enzymes. A different network of enzymes and endogenous metabolites restrains lipid peroxidation by interfering with the initiation or propagation of this process. This emerging understanding is informing new approaches to treat disease by modulating lipid metabolism to enhance or inhibit ferroptosis.

Lauren E Pope

Scott J Dixon

Regulation of ferroptosis by lipid metabolism.

Drastic epigenetic reprogramming takes place during preimplantation development, leading to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in remodeling of the epigenomes can cause severe developmental defects, including embryonic lethality. However, how chromatin modifications and chromatin organization are reprogrammed upon fertilization in mammals has long remained elusive. Here, we review recent progress in understanding how the epigenome is dynamically regulated during early mammalian development. The latest studies, including many from genome-wide perspectives, have revealed unusual principles of reprogramming for histone modifications, chromatin accessibility, and 3D chromatin architecture. These advances have shed light on the regulatory network controlling the earliest development and maternal-zygotic transition.

Qianhua Xu

Wei Xie

Epigenome in Early Mammalian Development: Inheritance, Reprogramming and Establishment.

In preparation for cell division, the genome must be copied with high fidelity. However, replisomes often encounter obstacles, including bulky DNA lesions caused by reactive metabolites and chemotherapeutics, as well as stable nucleoprotein complexes. Here, we discuss recent advances in our understanding of TRAIP, a replisome-associated E3 ubiquitin ligase that is mutated in microcephalic primordial dwarfism. In interphase, TRAIP helps replisomes overcome DNA interstrand crosslinks and DNA-protein crosslinks, whereas in mitosis it triggers disassembly of all replisomes that remain on chromatin. We describe a model to explain how TRAIP performs these disparate functions and how they help maintain genome integrity.

R Alex Wu

David S Pellman

Johannes C Walter

The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome.

Jiawei Yan

Tiffany Horng

Lipid Metabolism in Regulation of Macrophage Functions

脂质代谢在巨噬细胞功能调控中的作用

Increased protein O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) has emerged as a hallmark of mammalian cell activation, contributing to Warburg-like metabolic rewiring allowing the acquisition of new functionalities. Recent advances indicate that O-GlcNAcylation promotes the activity of transcriptional regulators driving gene expression reprogramming. This may offer new therapeutic opportunities in a broad spectrum of pathological conditions.

Ninon Very

Bart Staels

Jérôme Eeckhoute

Increased O-GlcNAcylation connects metabolic to transcriptional reprogramming during pathophysiological cell activation.

O-GlcNAc糖基化增加在病理性细胞激活过程中连接代谢与转录重编程

DNA-protein crosslinks (DPCs) are highly toxic DNA lesions that are relevant to multiple human diseases. They are caused by various endogenous and environmental agents, and from the actions of enzymes such as topoisomerases. DPCs impede DNA polymerases, triggering replication-coupled DPC repair. Until recently the consequences of DPC blockade of RNA polymerases remained unclear. New methodologies for studying DPC repair have enabled the discovery of a transcription-coupled (TC) DPC repair pathway. Briefly, RNA polymerase II (RNAPII) stalling initiates TC-DPC repair, leading to sequential engagement of Cockayne syndrome (CS) proteins CSB and CSA, and to proteasomal degradation of the DPC. Deficient TC-DPC repair caused by loss of CSA or CSB function may help to explain the complex clinical presentation of CS patients.

Christopher J Carnie

Stephen P Jackson

Julian Stingele

Transcription-coupled repair of DNA–protein crosslinks

转录偶联的DNA-蛋白质交联修复

Yandong Zhou

Youjun Wang

Donald L. Gill

Inter-membrane control of junctional InsP3 receptors by PIP2

膜间控制由PIP2介导的连接型InsP3受体

The role of primary cilia has recently garnered significant attention in the field of neurodegeneration. This review explores the diversity of primary cilia in the mature brain and their interrelationships with a multitude of cellular structures, including axons and synapses. Importantly, an overview of the growing prominence of ciliary-related dysfunctions in neurodegenerative diseases is summarized, with a special emphasis on Parkinson's disease (PD) and neuropsychiatric disorders.

Polina Volos

Kenshiro Fujise

Nisha Mohd Rafiq

Roles for primary cilia in synapses and neurological disorders

初级纤毛在突触和神经疾病中的作用

The nonreceptor tyrosine phosphatases (PTPS) SHP1 and SHP2 have crucial roles in dephosphorylating an array of substrates involved in pathways comprising receptor tyrosine kinases (RTKs) and immune receptors. This regulation maintains a delicate balance between the activation and inhibition of signal transduction, ensuring appropriate biological outcomes. In this review, we summarize research focused on elucidating the functions of SHP1 and SHP2 in hematopoiesis, immune regulation, and tumor biology, emphasizing recent findings related to cancer-driven immune evasion. Furthermore, we highlight the significant effects of SHP1 and SHP2 inhibitors in enhancing cancer treatment, specifically through the facilitation of chemotherapy and augmentation of immune activation.

Yijun Zhao

Linjia Jiang

Targeting SHP1 and SHP2 to suppress tumors and enhance immunosurveillance

靶向SHP1和SHP2以抑制肿瘤并增强免疫监视

Abbreviation	Trends Cell Biology
Journal Impact	12.95
Quartiles(Global)	CELL BIOLOGY(Q1)

ISSN	0962-8924, 1879-3088
h-index	263
Top Journals	Yes

Publication Information	Publisher: Elsevier Ltd，Publishing cycle: Monthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1991，Proportion of original research papers: 7.04%，Self Citation Rate:0.80%， Gold OA Rate: 37.16%
Average review cycle	网友分享经验：较慢,6-12周
Average recruitment ratio	网友分享经验：多是约稿

Trends in Cell Biology

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