TRENDS IN CELL BIOLOGY 是分子和细胞生物学领域领先的评论期刊之一。每月发表的评论文章监控当前细胞生物学研究的广度和深度，及时报告新的发展，整合方法、学科和原则。所有文章均由顶尖科学家委托，然后经过严格的同行评审，确保平衡和准确性。除了评论之外，TRENDS IN CELL BIOLOGY 还发表意见文章，这些文章跟踪趋势并提供创新想法，以洞察新发展的影响并提出未来方向。

Trends in Cell Biology is one of the leading review journals in the field of molecular and cell biology. The journal publishes monthly review articles that monitor the breadth and depth of current research in cell biology, reporting new developments in a timely manner and integrating methods, disciplines, and principles. All articles are commissioned by top scientists and undergo rigorous peer review to ensure balance and accuracy. In addition to review articles, Trends in Cell Biology also publishes opinion pieces that track trends and provide innovative ideas to insightfully assess the impact of new developments and suggest future directions.

《Trends in Cell Biology》是分子和细胞生物学领域领先的评论期刊之一。该期刊每月发表的评论文章监测当前细胞生物学研究的广度和深度，及时报道新的发展，整合方法、学科和原则。所有文章均由顶尖科学家委托，并经过严格的同行评审，以确保内容的平衡和准确性。除了评论文章外，《Trends in Cell Biology》还发表意见文章，这些文章跟踪趋势并提供创新想法，以洞察新发展的影响并提出未来的研究方向。

Trends in Cell Biology

The majority of human mRNAs generate alternative 3' untranslated regions (UTRs) through various processes, including RNA modifications such as RNA editing, m6A methylation, and alternative polyadenylation (APA), with 3'UTR splicing as an emerging mechanism. Multiple factors, ranging from the genome to transcriptome level, regulate these processes and contribute to 3'UTR heterogeneity. Genomic variants in 3'UTR regions as well as aberrant 3'UTR processing alter the transcriptomic landscape and are associated with cancer. Increasing evidence, aided by high-resolution sequencing technologies and large-scale computational analyses, points towards potential crosstalk between these processes, whose deregulation may further contribute to cancer pathogenesis. In-depth characterization of these events will increase our appreciation of their significance and help to drive therapeutic development in this field.

Jia Jia Chan

Hossein Tabatabaeian

Yvonne Tay

Trends in cell biology

Trends Cell Biol

3'UTR heterogeneity and cancer progression.

Gennaro Napolitano

Chiara Di Malta

Andrea Ballabio

Non-canonical mTORC1 signaling at the lysosome

Detection and conversion of mechanical forces into biochemical signals is known as mechanotransduction. From cells to tissues, mechanotransduction regulates migration, proliferation, and differentiation in processes such as immune responses, development, and cancer progression. Mechanosensitive structures such as integrin adhesions, the actin cortex, ion channels, caveolae, and the nucleus sense and transmit forces. In vitro approaches showed that mechanosensing is based on force-dependent protein deformations and reorganizations. However, the mechanisms in cells remained unclear since cell imaging techniques lacked molecular resolution. Thanks to recent developments in super-resolution microscopy (SRM) and molecular force sensors, it is possible to obtain molecular insight of mechanosensing in live cells. We discuss how understanding of molecular mechanotransduction was revolutionized by these innovative approaches, focusing on integrin adhesions, actin structures, and the plasma membrane.

Filipe Nunes Vicente

Tianchi Chen

Olivier Rossier

Grégory Giannone

Novel imaging methods and force probes for molecular mechanobiology of cytoskeleton and adhesion

Solute carrier transporters (SLCs) mediate nutrient and metabolite cellular homeostasis. Immune cells depend on SLCs to induce rapid and robust metabolic reprogramming, thereby controlling diverse immunological responses. Recent studies hint toward an important role of SLCs in immunity. Here, we review the emerging roles of SLCs in immunotherapy via modifying the metabolism and effector functions of immune cells. We focus on the roles of three major nutrient (glucose, amino acid, and lipid)-related transporters in immunity of representative cells [T cells, dendritic cells (DCs), natural killer (NK) cells, and macrophages) in innate and adaptive immunity. Other SLCs, such as ion transporters are also briefly discussed. Finally, we propose some potential strategies for targeting SLCs to augment tumour immunotherapy.

Ruiqun Chen

Ligong Chen

Solute carrier transporters: emerging central players in tumour immunotherapy.

As a member of the large family of intermediate filaments (IFs), vimentin has emerged as a highly dynamic and versatile cytoskeletal protein involved in many key processes of wound healing. It is well established that vimentin is involved in epithelial-mesenchymal transition (EMT) during wound healing and metastasis, during which epithelial cells acquire more dynamic and motile characteristics. Moreover, vimentin participates in multiple cellular activities supporting growth, proliferation, migration, cell survival, and stress resilience. Here, we explore the role of vimentin at each phase of wound healing, with focus on how it integrates different signaling pathways and protects cells in the fluctuating and challenging environments that characterize a healing tissue.

Leila S Coelho-Rato

Sepideh Parvanian

Mayank Kumar Modi

John E Eriksson

Vimentin at the core of wound healing.

Yandong Zhou

Youjun Wang

Donald L. Gill

Inter-membrane control of junctional InsP3 receptors by PIP2

膜间控制由PIP2介导的连接型InsP3受体

The role of primary cilia has recently garnered significant attention in the field of neurodegeneration. This review explores the diversity of primary cilia in the mature brain and their interrelationships with a multitude of cellular structures, including axons and synapses. Importantly, an overview of the growing prominence of ciliary-related dysfunctions in neurodegenerative diseases is summarized, with a special emphasis on Parkinson's disease (PD) and neuropsychiatric disorders.

Polina Volos

Kenshiro Fujise

Nisha Mohd Rafiq

Roles for primary cilia in synapses and neurological disorders

初级纤毛在突触和神经疾病中的作用

The nonreceptor tyrosine phosphatases (PTPS) SHP1 and SHP2 have crucial roles in dephosphorylating an array of substrates involved in pathways comprising receptor tyrosine kinases (RTKs) and immune receptors. This regulation maintains a delicate balance between the activation and inhibition of signal transduction, ensuring appropriate biological outcomes. In this review, we summarize research focused on elucidating the functions of SHP1 and SHP2 in hematopoiesis, immune regulation, and tumor biology, emphasizing recent findings related to cancer-driven immune evasion. Furthermore, we highlight the significant effects of SHP1 and SHP2 inhibitors in enhancing cancer treatment, specifically through the facilitation of chemotherapy and augmentation of immune activation.

Yijun Zhao

Linjia Jiang

Targeting SHP1 and SHP2 to suppress tumors and enhance immunosurveillance

靶向SHP1和SHP2以抑制肿瘤并增强免疫监视

The superfamily of hydroxysteroid dehydrogenases (HSDs) has been well-characterized as enzymes in lipid metabolism, and especially in steroid hormone metabolism from bacteria to mammals. Recently, a subset of HSDs members, including 3β-HSD, 11β-HSD, and 17β-HSD, have been shown to be lipid droplet (LD)-associated proteins that are involved in LD dynamics beyond their canonical functions. This review summarizes current understanding of these LD-associated HSD proteins, focusing on how they regulate different LDs with respect to distinct neutral lipids including triacylglycerols (TAGs), cholesterol esters (CEs), and retinyl esters (REs), the evolutionally conserved role of some LD-associated 17β-HSDs in preventing lipolysis, and specific targeting of HSDs for the treatment of metabolic diseases and viral infections.

Bin Liang

Lin Fu

Pingsheng Liu

Regulation of lipid droplet dynamics and lipid homeostasis by hydroxysteroid dehydrogenase proteins

羟基类固醇脱氢酶蛋白对脂滴动态和脂质稳态的调控

Tumors often face energy deprivation due to mutations, hypoxia, and nutritional deficiencies within the harsh tumor microenvironment (TME), and as an effect of anticancer treatments. This metabolic stress triggers adaptive reprogramming of mRNA translation, which in turn adjusts metabolic plasticity and associated signaling pathways to ensure tumor cell survival. Emerging evidence is beginning to reveal the complex interplay between metabolism and mRNA translation, shedding light on the mechanisms that synchronize ribosome assembly and reconfigure translation programs under metabolic stress. This review explores recent advances in our understanding of the coordination between metabolism and mRNA translation, offering insights that could inform therapeutic strategies targeting both cancer metabolism and translation, with the aim of disrupting cancer cell plasticity and survival.

Abbreviation	Trends Cell Biology
Journal Impact	12.95
Quartiles(Global)	CELL BIOLOGY(Q1)

ISSN	0962-8924, 1879-3088
h-index	263
Top Journals	Yes

Publication Information	Publisher: Elsevier Ltd，Publishing cycle: Monthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1991，Proportion of original research papers: 7.04%，Self Citation Rate:0.80%， Gold OA Rate: 37.16%
Average review cycle	网友分享经验：较慢,6-12周
Average recruitment ratio	网友分享经验：多是约稿

Trends in Cell Biology

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