JOURNAL OF TOXICOLOGICAL SCIENCES (J. TOXICOL. SCI.) 是一本科学期刊，发表关于药物、食品添加剂、食品污染物和环境污染物等物质的毒性机制和意义的研究。一般不能接受关于含有不明化合物的提取物和混合物的毒性和影响的论文。

The Journal of Toxicological Sciences (J. TOXICOL. SCI.) is a scientific journal dedicated to publishing research on the toxic mechanisms and significance of substances such as drugs, food additives, food contaminants, and environmental pollutants. The journal generally does not accept papers on the toxicity and effects of extracts and mixtures containing unidentified compounds.

《Journal of Toxicological Sciences》（J. TOXICOL. SCI.）是一本科学期刊，专注于发表关于药物、食品添加剂、食品污染物和环境污染物等物质的毒性机制及其意义的研究。该期刊一般不接受关于含有不明化合物的提取物和混合物的毒性及其影响的论文。

Journal of Toxicological Sciences

Hongbin Wang

Wei Li

The Journal of Toxicological Sciences

Puerarin alleviates the high glucose-induced oxidative stress via the RAGE/PKC/NOX4 axis in renal mesangial cells

葛根素通过RAGE/PKC/NOX4轴减轻高糖诱导的肾小球系膜细胞氧化应激

Jiehuan Xu

Jianlin Chen

Dao Wang

Yaojun Li

Ping Lian

Xiaozhu Wu

Rong Yan

Nafamostat mesylate sensitizes ovarian cancer cells to carboplatin by promoting the ZNF24-mediated inhibition of WNT2B

甲磺酸萘莫司他通过促进ZNF24介导的WNT2B抑制增强卵巢癌细胞对卡铂的敏感性

Xinyu Zou

Yousuke Watanabe

Shunsuke Ozawa

Yuri Ebizuka

Momoka Shobudani

Yuri Sakamaki

Tetsuhito Kigata

Meilan Jin

Fumiyo Saito

Yumi Akahori

Susumu Yamashita

Makoto Shibutani

Gene expression profiles of neuroinflammatory responses in broad brain regions in rats repeatedly administered with &lt;i&gt;N&lt;/i&gt;-methyl-&lt;i&gt;N&lt;/i&gt;-nitrosourea for 28 days

大鼠反复给予N-甲基-N-亚硝基脲28天后广泛脑区神经炎症反应的基因表达谱

Hidenori Suto

Keiko Ogata

Kenta Minami

Akira Sato

Naruto Tomiyama

Tadashi Kosaka

Hitoshi Hojo

Naofumi Takahashi

Hiroaki Aoyama

Tomoya Yamada

Perinatal maternal exposure to high-dose sodium phenobarbital in the modified Comparative Thyroid Assay: no significant reduction in thyroid hormones in pups despite notable effects in dams

改良比较甲状腺检测中围产期母体暴露于高剂量苯巴比妥钠：尽管母体有显著影响，幼崽甲状腺激素无显著减少

ICH S3A Q&A focused on microsampling (MS) was published to help accelerate the use of MS and states that MS is useful because toxicokinetic (TK) evaluation with conventional blood sampling volume requires many animals for TK satellite groups; however, there are few reports of MS application in mice. We investigated the influence of MS on toxicity evaluation in mice by comparing the toxicity parameters with and without MS after a single oral administration of 1-naphthylisothiocyanate (ANIT), a hepatotoxic substance. Blood samples (50 µL/point) were collected from the tail vein of 3 mice per group at 2 or 3 time points during a 24-hr period, and toxicity was evaluated 2 days after administration. ANIT-related changes suggesting liver or gallbladder injury were noted in blood chemistry and histopathology. Some of these changes such as increases in focal hepatocyte necrosis and inflammatory cell infiltration in the liver as well as mucosal epithelium necrosis in the gallbladder were apparently influenced by MS. A tendency to anemia was noted in animals with MS but not without MS, which was also noted in the vehicle-treated controls, suggesting influence of blood loss. The current results indicate that ANIT hepatotoxicity could be evaluated in mice in which blood samples were collected by MS for most parameters; however, parameters in anemia and pathology in the liver and gallbladder were influenced by MS in this study condition with ANIT. Therefore, MS application in mice should be carefully considered.

Kazuaki Takahashi

Shun Kawaguchi

Tomohiro Ikeda

Yuki Tomonari

Takeshi Funakoshi

Keiko Nakai

Tooru Fujimoto

Dai Yamamoto

Takayuki Okamura

Hideomi Uchida

Yoshiro Saito

Seiji Otake

Effects of microsampling on toxicity evaluation of 1-naphthylisothiocyanate (ANIT), a hepatotoxic substance, in a mouse toxicity study

微采样对1-萘基异硫氰酸酯（ANIT）在小鼠毒性研究中毒性评估的影响

We conducted a two-year inhalation study of butyraldehyde using F344/DuCrlCrlj rats. The rats were exposed to 0, 300, 1,000 and 3,000 ppm (v/v) for 6 hr/day, 5 days/ week for 104 weeks using whole-body inhalation chambers. The incidence of squamous cell carcinoma of the nasal cavity was increased in the 3,000 ppm groups of both male and female rats, with Fisher's exact test and the Peto test indicating that the incidence was significant. In addition to squamous cell carcinoma in the nasal cavity, in the 3,000 ppm groups one male had an adenosquamous carcinoma, one male had a carcinosarcoma, one male had a sarcoma NOS (Not Otherwise Specified), and one female had a squamous cell papilloma in the nasal cavity. The combined incidence of squamous cell carcinoma, adenosquamous carcinoma and carcinosarcoma was significantly increased in male rats and the combined incidence of squamous cell papilloma and carcinoma was significantly increased in female. Based on these results, we conclude that there is clear evidence of butyraldehyde carcinogenicity in male and female rats.

Abbreviation	J. Toxicol. Sci.
Journal Impact	1.97
Quartiles(Global)	TOXICOLOGY(Q4)

ISSN	0388-1350, 1880-3989
h-index	59

Publication Information	Publisher: Japanese Society of Toxicology，Publishing cycle: Quarterly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1976，Proportion of original research papers: 98.08%，Self Citation Rate:5.60%， Gold OA Rate: 99.43%
Average review cycle	网友分享经验：偏慢,4-8周
Average recruitment ratio	网友分享经验：容易

Journal of Toxicological Sciences

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Puerarin alleviates the high glucose-induced oxidative stress via the RAGE/PKC/NOX4 axis in renal mesangial cells

Nafamostat mesylate sensitizes ovarian cancer cells to carboplatin by promoting the ZNF24-mediated inhibition of WNT2B

Gene expression profiles of neuroinflammatory responses in broad brain regions in rats repeatedly administered with <i>N</i>-methyl-<i>N</i>-nitrosourea for 28 days

Perinatal maternal exposure to high-dose sodium phenobarbital in the modified Comparative Thyroid Assay: no significant reduction in thyroid hormones in pups despite notable effects in dams

Effects of microsampling on toxicity evaluation of 1-naphthylisothiocyanate (ANIT), a hepatotoxic substance, in a mouse toxicity study

Puerarin alleviates the high glucose-induced oxidative stress via the RAGE/PKC/NOX4 axis in renal mesangial cells

Nafamostat mesylate sensitizes ovarian cancer cells to carboplatin by promoting the ZNF24-mediated inhibition of WNT2B

Gene expression profiles of neuroinflammatory responses in broad brain regions in rats repeatedly administered with <i>N</i>-methyl-<i>N</i>-nitrosourea for 28 days

Perinatal maternal exposure to high-dose sodium phenobarbital in the modified Comparative Thyroid Assay: no significant reduction in thyroid hormones in pups despite notable effects in dams

Carcinogenicity of butyraldehyde in rats by a two-year inhalation study