About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science.   Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers.   The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.

Acta Medica Bulgarica was established in 1973, initiated by the Publishing House of Medicine and Physical Culture, under the leadership of its former director, Mr. Traian Ivanov. The Ministry of Health set up and subsidized a new medical journal that was to be published exclusively in English, aiming to reflect the status and achievements of Bulgarian medical science. This initiative overcame the language barrier and established stable relations with the international medical community, large libraries, and university centers. The renowned international scientist, Professor Assen A. Hadjiolov, was elected as the editor-in-chief by the first editorial board, and the journal was named Acta Medica Bulgarica.

《Acta Medica Bulgarica》创办于1973年，源于医学与体育文化出版社的倡议，时任社长Traian Ivanov先生的推动下，保健部设立并资助了一本新的医学杂志，该杂志仅用英语出版，旨在反映保加利亚医学科学的现状和成就。通过这一举措，克服了语言障碍，建立了与国际医学界、大型图书馆和大学中心的稳定关系。著名国际科学家Assen A. Hadjiolov教授被第一届编辑部选为主编，杂志因此命名为《Acta Medica Bulgarica》。

Acta Medica Bulgarica

Abstract Problem statement Oocyte cryopreservation for non-medical reasons has been widely promoted among young women who tend to delay their reproduction. As the methodology has proved its safety and efficiency in the field of assisted reproduction technology and the embryo laboratory, the interest in oocyte cryopreservation has increased highly. However, do social freezers ever come back and use these oocytes, or they keep them as a safety boat with no real near-future plans for reproduction? Methods The following study has been performed as a retrospective analysis of 296 women who had oocyte freezing procedure for non-medical (social) reasons, medical conditions (oncological treatment) and oocyte donation from January 2013 to June 2023 at Medical Complex Ob/Gyn “Dr Shterev” – Sofia, Bulgaria. Results Throughout the observed period, 190 women with 221 procedures vitrified their oocytes for future use. Only 9.47% of them had medical conditions and 7.36% were hindered to use their reproductive gametes at the day of the oocyte retrieval (absence of spermatozoa, sickness). The average age of the women in this group was 35.59 ± 1.5 years and the mean number of cryopreserved oocytes was 5.63 ± 1.4 per women. Compared to social cryopreserves, and bound to the Bulgarian legislation, the 106 women who donated their oocytes were younger (28.86 ± 1.5 years (p &lt; 0.05)) with 7.34 ± 1.7 (p &lt; 0.05) cryopreserved oocytes per donor. As the clinic has well represented program for oocyte donation 82.1% of the donors were used. In result, there were 37 clinical pregnancies with 47 children born. In the same period, only 46 (24.2%) women who stored their own gametes in our cryobank came back and claimed them for assisted reproduction. Nine clinical pregnancies had been registered and 10 children were born. An intriguing fact we can point from the medical history of the clear social freezers (SF) is the record of previous procedure(s) for abortion on demand. It was reported for 12% of the women in this group. Conclusion According to the results we observed as evident that patients need more clarity towards the procedures for oocyte cryopreservation and consequent fertility treatment. We should rise more awareness to the most preferable age for cryopreservation and number of oocytes to be stored.

D. Dyulgerova-Nikolova

I. Antonova

L. Valkova

T. Timeva

M. Yunakova

T. Milachich

Aspects on Social Egg Freezing – Current State in Bulgaria

社会卵子冷冻的现状——保加利亚的现状

Abstract Breast cancer is the cancer with the greatest incidence in the world by 2020. This cancer has a high mortality rate, has the capability of metastasizing, and causes damage to important organs of the human body. Therefore, a lot of studies have been done to find the best therapy to overcome this problem. However, cancer has various special abilities that make it survive and continue to invade its host body, for example, the ability to evade its host immune system by several mechanisms. One of the potential cancer therapies is virotherapy. Virotherapy is a therapeutic method using viruses to destroy cancer cells. Several mechanisms can be provided by viruses, such as stimulating the host immune system and inducing apoptosis of cancer cells. Especially for breast cancer, there are 4 groups of viruses based on their genome that have oncolytic capability, such as the dsDNA, dsRNA, + ssRNA, and -ssRNA groups. Currently, there are several therapeutic virotherapy-based modalities for breast cancer that are in clinical trial phases. Each trial has shown positive results in developing virotherapy for breast cancer.

I. Sasmana

P. Putri

N. Dewi

I. Supadmanaba

D. Wihandani

Current Development of Virotherapy in Breast Cancer: A Brief Review

乳腺癌病毒疗法的最新进展：简要综述

Abstract Objective. To investigate the impact of thrombophilia on pregnancy-associated plasma protein A (PAPP-A) and human chorionic gonadotropin (hCG) and the nuchal translucency (NT) during the first trimester of the pregnancy. Material and Methods. A case-control research study was conducted at a prenatal outpatient unit of a tertiary referral hospital in Burgas, Bulgaria, between January 1st, 2021 and March 31st, 2023. A total of 309 pregnant women patients with congenital thrombophilia took part in the experimental research of the study, while 150 healthy pregnant women patients without evidence of thrombophilia were the control sample. Results. A statistically significant difference in the pregnancy-associated plasma protein A (PAPP-A), t(369) = 1.028, p &lt; 0.05 between the two groups, with the experimental group reporting lower multiples of median (MoM) values as compared to the control group. The results showed statistically significant differences in the median values of PAPP-A and NT between the different types of inherited thrombophilia but no statistically significant difference in the median values of HCG. The results showed no statistically significant difference in age, gravidity, or parity between the experimental and control groups. Conclusion. The first trimester combined aneuploidy screening parameters are important in prenatal detection of the pregnancy status for identification of any variations in terms of chromosomal and fetal structural anomalies. Inherited thrombophilia adversely impacts the aneuploidy screening parameters during the first trimester of pregnancy.

Z. Kirovakov

N. Hinkova

E. Konova

The Impact of Inherited Thrombophilia on First Trimester Combined Aneuploidy Screening Parameters

遗传性血栓形成倾向对孕早期联合非整倍体筛查参数的影响

Abstract Assessing the particular trends and factors influencing antibiotic prescription practices for pediatric patients by inpatient and outpatient physicians in Bulgaria is essential for pinpointing areas needing improvement and devising strategies to encourage judicious use of antibiotics. The aim of this study is to offer practical insights for both hospital and outpatient care. By recognizing and comprehending the specific details of antibiotic usage in pediatric healthcare, this study seeks to facilitate the creation of tailored stew-ardship strategies to address the growing challenge of antimicrobial resistance. A cross-sectional, multicenter survey was conducted between September and November 2022, involving specialists from various medical fields. The study used a 4-point Likert scale to evaluate the most prevalent clinical scenarios in which antibiotics were prescribed. A total of 222 physicians participated in the survey, with 108 respondents chosen for analysis. Their primary patient population consisted of at least 25% children. The study’s results highlight notable variations in antibiotic prescription patterns between general practitioners and outpatient physicians in Bulgaria. Specifically, general practitioners were found to have a higher tendency to prescribe antibiotics before holidays or weekends compared to outpatient physicians. Moreover, GPs in Bulgaria displayed an increased likelihood of prescribing antibiotics when they had personal familiarity with the patient and did not consider further tests necessary. They also exhibited lower rates of prescribing antibiotics based on antibiogram and blood test results compared to outpatient physicians. Healthcare providers play a crucial role in addressing antimicrobial resistance, highlighting the necessity of their proactive participation in combating this global health concern. Despite being aware of the issue, there is need for additional education and interventions to enhance appropriate prescribing practices. The authors underline the significance of adopting a well-balanced approach to antibiotic prescription, taking into account both individual patient requirements and potential public health implications associated with antibiotic misuse.

K. Zaykova

S. P. Nikolova

R. Pancheva

A. Serbezova

Antibiotic Prescribing Practices to Children Among in- and Outpatient Physicians in Bulgaria

保加利亚门诊和住院医生对儿童的抗生素处方实践

Abstract The numerous attempts to prove a therapeutic effect of low-dose colchicine for the treatment of Coronavirus disease-2019 (COVID-19) have been discouraging. Increase of doses, however, leads to accumulation in leukocytes and inhibition of the cytokine storm thus preventing COVID-19 complications and hospitalizations. Hospital mortality drops up to 7-fold, while outpatients practically do not reach hospitalization.

Publication Information	Publisher: Walter de Gruyter GmbH，Publishing cycle: ，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2001，Proportion of original research papers: 0.00%，Self Citation Rate:N.A.， Gold OA Rate: 0.00%
Average review cycle	网友分享经验：25 Weeks

Acta Medica Bulgarica

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Aspects on Social Egg Freezing – Current State in Bulgaria

Current Development of Virotherapy in Breast Cancer: A Brief Review

The Impact of Inherited Thrombophilia on First Trimester Combined Aneuploidy Screening Parameters

Antibiotic Prescribing Practices to Children Among in- and Outpatient Physicians in Bulgaria

High Colchicine Doses Are Really Silver Bullets Against COVID-19

Aspects on Social Egg Freezing – Current State in Bulgaria

Current Development of Virotherapy in Breast Cancer: A Brief Review

The Impact of Inherited Thrombophilia on First Trimester Combined Aneuploidy Screening Parameters

Antibiotic Prescribing Practices to Children Among in- and Outpatient Physicians in Bulgaria

High Colchicine Doses Are Really Silver Bullets Against COVID-19

ISSN	0324-1750, 2719-5384
h-index	7