《风湿病学杂志》是由 EARL D. SILVERMAN 编辑的国际月刊。该杂志收录了来自风湿病学和相关领域的科学家关于临床主题的研究文章，以及会议记录作为常规问题的补充。我们为风湿病学服务 41 年的亮点包括：开创性和挑衅性的社论，例如“倒金字塔”、著名的儿科风湿病学、OMERACT 和加拿大风湿病学协会的会议记录、COCHRANE 肌肉骨骼评论以及新兴疗法的补充。

The Journal of Rheumatology is an international monthly journal edited by EARL D. SILVERMAN. It publishes research articles on clinical topics from scientists in rheumatology and related fields, along with regular supplements of conference proceedings. Highlights of our 41 years of service to rheumatology include groundbreaking and thought-provoking editorials, such as 'The Inverted Pyramid', notable pediatric rheumatology, OMERACT and Canadian Rheumatology Association conference proceedings, COCHRANE musculoskeletal reviews, and supplements on emerging therapies.

《风湿病学杂志》是由EARL D. SILVERMAN编辑的国际月刊。该杂志发表来自风湿病学及相关领域的科学家们关于临床主题的研究文章，并定期补充会议记录。我们为风湿病学服务41年的亮点包括：开创性和引人深思的社论，如“倒金字塔”、著名的儿科风湿病学、OMERACT和加拿大风湿病学协会的会议记录、COCHRANE肌肉骨骼评论以及新兴疗法的补充。

Journal of Rheumatology

Autoinflammatory disease (AID) is a vast spectrum of disorders characterized by recurrent attacks of sterile inflammation. Since the first cloning of the familial Mediterranean fever gene in 1997, there has been a rapid rate of discovery of new AIDs. As of 2022, there have been 485 inborn errors of immunity documented by the International Union of Immunological Societies, for which many display aspects of autoinflammation. The pathophysiology of AIDs is complex. Although many are caused by rare mutations in genes that govern innate immunity, others are polygenic, where disease expression is thought to be triggered by environmental factors in genetically predisposed hosts. AIDs range in prevalence from common entities like gout to ultrarare monogenic diseases. Whereas AIDs were initially studied in pediatric populations, it is now apparent that they can present in adulthood and even in the elderly. AIDs can be clinically challenging given their rarity, as well as the heterogeneity in presentation and underlying etiology. Although the care of AIDs can span medical disciplines, the rheumatologist often plays a central role given the inflammatory nature of these illnesses. In this review, we explore the current understanding of the pathophysiology of these complex conditions and propose a classification system for AIDs. We place an emphasis on AIDs that present to the adult rheumatologist and discuss important AIDs that can mimic more classic rheumatic diseases such as systemic lupus erythematosus and inflammatory arthritis. Finally, we offer an approach to the clinical assessment, diagnosis, and management of AIDs.

Jason An

Ashish Marwaha

Ronald M. Laxer

The Journal of Rheumatology

Autoinflammatory Diseases – A Review

自身炎症性疾病综述

Nail involvement in psoriatic diseases causes significant physical and functional disabilities. Evaluating, measuring, and treating nail involvement is important in improving the health outcomes and quality of life among patients with psoriasis and psoriatic arthritis (PsA). We performed a systematic analysis of the literature on nail psoriasis to help inform an update of treatment recommendations by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).

April W. Armstrong

William Tuong

Thorvardur J. Love

Sueli Carneiro

Rachel Grynszpan

Steve S. Lee

Arthur Kavanaugh

Treatments for Nail Psoriasis: A Systematic Review by the GRAPPA Nail Psoriasis Work Group

指甲银屑病治疗：GRAPPA指甲银屑病工作组的系统综述

To develop and evaluate a Localized Scleroderma (LS) Skin Severity Index (LoSSI) and global assessments' clinimetric property and effect on quality of life (QOL).A 3-phase study was conducted. The first phase involved 15 patients with LS and 14 examiners who assessed LoSSI [surface area (SA), erythema (ER), skin thickness (ST), and new lesion/extension (N/E)] twice for inter/intrarater reliability. Patient global assessment of disease severity (PtGA-S) and Children's Dermatology Life Quality Index (CDLQI) were collected for intrarater reliability evaluation. The second phase was aimed to develop clinical determinants for physician global assessment of disease activity (PhysGA-A) and to assess its content validity. The third phase involved 2 examiners assessing LoSSI and PhysGA-A on 27 patients. Effect of training on improving reliability/validity and sensitivity to change of the LoSSI and PhysGA-A was determined.Interrater reliability was excellent for ER [intraclass correlation coefficient (ICC) 0.71], ST (ICC 0.70), LoSSI (ICC 0.80), and PhysGA-A (ICC 0.90) but poor for SA (ICC 0.35); thus, LoSSI was modified to mLoSSI. Examiners' experience did not affect the scores, but training/practice improved reliability. Intrarater reliability was excellent for ER, ST, and LoSSI (Spearman's rho = 0.71-0.89) and moderate for SA. PtGA-S and CDLQI showed good intrarater agreement (ICC 0.63 and 0.80). mLoSSI correlated moderately with PhysGA-A and PtGA-S. Both mLoSSI and PhysGA-A were sensitive to change following therapy.mLoSSI and PhysGA-A are reliable and valid tools for assessing LS disease severity and show high sensitivity to detect change over time. These tools are feasible for use in routine clinical practice. They should be considered for inclusion in a core set of LS outcome measures for clinical trials.

THASCHAWEE ARKACHAISRI

SOAMARAT VILAIYUK

SUZANNE LI

KATHLEEN M. O’NEIL

ELENA POPE

GLORIA C. HIGGINS

MARILYNN PUNARO

EGLA C. RABINOVICH

MARGALIT ROSENKRANZ

DANIEL A. KIETZ

PAUL ROSEN

STEVEN J. SPALDING

TERESA R. HENNON

KATHRYN S. TOROK

ELAINE CASSIDY

THOMAS A. MEDSGER

The Localized Scleroderma Skin Severity Index and Physician Global Assessment of Disease Activity: A Work in Progress Toward Development of Localized Scleroderma Outcome Measures

局限性硬皮病皮肤严重程度指数和医生对疾病活动度的整体评估：向局限性硬皮病结局指标发展的工作进展

Objective. To compare the incidence of venous thromboembolism (VTE) following total knee arthroplasty (TKA) between patients with rheumatoid arthritis (RA) and those with osteoarthritis (OA). Methods. The subjects were composed of 1084 Japanese patients with OA and 204 with RA. Primary effectiveness outcomes were any deep vein thrombosis (DVT) as detected by bilateral ultrasonography up to postoperative Day 10 (POD10) and pulmonary embolism (PE) up to POD28. The main safety outcomes were bleeding and death from any cause up to POD28. Plasma D-dimer levels were measured before and at POD10 after TKA. Results. The study cohort was composed of 1288 patients from 34 hospitals. There was no death up to POD28. PE occurred in 2 patients with OA and in no patients with RA. The incidence of primary effectiveness outcome was 24.3% and 24.0% in patients with OA and RA, respectively. The incidence of major bleeding up to POD28 was 1.3% and 0.5% in patients with OA and RA, respectively. No differences in the incidence of VTE (symptomatic/asymptomatic DVT plus PE) or bleeding were noted between patients with RA and OA. D-dimer levels on POD10 were significantly higher in patients with OA compared with those with RA. Also, D-dimer levels on POD10 were significantly lower in patients receiving fondaparinux than in patients without pharmacological prophylaxis. Conclusion. Despite some differences in demographic data, patients with RA and OA have equivalent risks of VTE and bleeding following TKA.

Masahiro Izumi

Kiyoshi Migita

Mashio Nakamura

Yuka Jiuchi

Tatsuya Sakai

Takayuki Yamaguchi

Tomihiko Asahara

Yuichiro Nishino

Seiji Bito

Shigeki Miyata

Kenji Kumagai

Makoto Osaki

Masaaki Mawatari

Satoru Motokawa

Risk of Venous Thromboembolism after Total Knee Arthroplasty in Patients with Rheumatoid Arthritis

类风湿性关节炎患者全膝关节置换术后静脉血栓栓塞的风险

Objective Evidence for an association of smoking with gout is conflicting. We assessed associations of current and past smoking with gout in an Aotearoa New Zealand (NZ) population. Methods Multivariable logistic regression analysis was performed on cross-sectional data from participants of NZ Māori (from 2 studies: Genetics of Gout in Aotearoa [GGA] study of 293 participants with gout and 431 without; and Ngāti Porou Hauora [NPH] study of 111 participants with gout and 42 without), Pacific people (257 participants with gout and 357 without), and European (694 participants with gout and 688 without) ancestry. Results Current smoking was not associated with gout in NZ Māori (GGA: adjusted odds ratio [aOR] 1.54, P = 0.13; NPH: aOR 3.02, P = 0.10), Pacific people (aOR 0.64, P = 0.21), or European (aOR 0.92, P = 0.80) cohorts. Ex-smoker status was associated with higher gout prevalence in Māori cohorts (GGA: aOR 1.71, P = 0.02; NPH: aOR 7.95, P &lt; 0.001), but not in Pacific people (aOR 1.10, P = 0.69) or European (aOR 1.18, P = 0.22) cohorts. Associations were independent of age, sex, BMI, alcohol intake, kidney function, hypertension, diabetes, physical activity, sugary drink consumption, education, and employment. No association of smoker status with serum urate concentrations was observed in participants without gout. Conclusion Ex-smoker status was associated with higher gout prevalence in people of NZ Māori ancestry. No association of current smoking with gout was observed across ancestral groups, raising uncertainties about the relevance of an association specific to ex-smokers.

Niamh C. Fanning

John F. Pearson

Nicola Dalbeth

Huti Watson

Tony R. Merriman

Lisa K. Stamp

Association of Past Smoking Status With Gout in Māori People in Aotearoa New Zealand

过去吸烟状况与新西兰毛利人痛风之间的关联

Mark C. Hwang

Karim Doughem

MinJae Lee

Lianne S. Gensler

Mariko L. Ishimori

Michael M. Ward

Matthew A. Brown

Amirali Tahanan

Michael H. Weisman

Mohammad H. Rahbar

John D. Reveille

Radiographic Axial Spondyloarthritis (Ankylosing Spondylitis) Commencing Late in Life

放射学轴性脊柱关节炎（强直性脊柱炎）晚年开始

Wilson Bautista-Molano

Broadening the Landscape for Treatment Recommendations in the Management of Axial Spondyloarthritis

拓宽轴性脊柱关节炎管理中的治疗建议范围

Objective Patients with psoriatic arthritis (PsA) in randomised controlled trials (RCTs) may not reflect patients in clinical practice. The objective was to perform a meta-analysis of PsA patients' characteristics in RCTs of biologic disease-modifying antirheumatic drugs (bDMARDs), and to compare them to patient profiles in a real-world study. Methods Data sources: (a) Scoping literature review of phase III RCTs of bDMARDs in PsA published 2015-2020; (b) International observational study of PsA patients starting a bDMARD enrolled in 2015–2018 (PsABio: NCT02627768 ). Data collected at baseline included swollen and tender joint counts (SJC/TJC), enthesitis, skin involvement (body surface area -BSA-), C-reactive protein (CRP), physician global assessment (PhGA) and patient-reported outcomes (HAQ, pain). Univariate random-effects meta-analysis was conducted to calculate pooled means and proportions. Results Overall, 5654 patients from 10 RCTs were compared to 930 PsABio patients. Demographic data were similar. SJC/TJC were higher in RCTs than in PsABio (pooled means, 11.8/21.5 vs 5.7/11.9 respectively); enthesitis was more frequent in RCTs (64.7% vs 48.2%); as were patients with a BSA≥3% (62.2% vs 54.0%). PhGA was higher in RCTs (59.7mm vs 54.1mm). In contrast, patient-reported outcomes were similar, while CRP was significantly higher in PsABio (1.1 vs 1.4mg/dl). Conclusion PsA patients starting a bDMARD in RCTs had highly active disease and a high patient-reported disease burden. In contrast, PsABio real-world patients starting a bDMARD had lower joint counts, skin disease and PhGA, but presented with similar patient-reported disease burden. The extrapolation of RCT data in clinical practice should take these elements into account.

Gelsomina Alle

Clementina Lopez-Medina

Stefan Siebert

Frédéric Lavie

Wim Noel

Josef S. Smolen

Laure Gossec

Patient profiles in randomised controlled trials versus a real-world study, in psoriatic arthritis: scoping review and meta-analysis.

银屑病关节炎随机对照试验与真实世界研究中的患者特征：范围综述与荟萃分析。

Laura Ross

Stephanie Bond

Jessica A. Day

Pursuing Gender Equity in Rheumatology: Thinking Beyond Gender Representation to Assess Gender Equality

追求风湿病学中的性别平等：超越性别代表性思考性别平等

Abbreviation	J Rheumatol
Journal Impact	3.80
Quartiles(Global)	RHEUMATOLOGY(Q2)

ISSN	0315-162X, 1499-2752
h-index	196

Publication Information	Publisher: Journal of Rheumatology，Publishing cycle: Monthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1974，Proportion of original research papers: 95.83%，Self Citation Rate:8.30%， Gold OA Rate: 1.28%
Average review cycle	网友分享经验：平均1.0个月
Average recruitment ratio	网友分享经验：较易

Journal of Rheumatology

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Autoinflammatory Diseases – A Review

Treatments for Nail Psoriasis: A Systematic Review by the GRAPPA Nail Psoriasis Work Group

The Localized Scleroderma Skin Severity Index and Physician Global Assessment of Disease Activity: A Work in Progress Toward Development of Localized Scleroderma Outcome Measures

Risk of Venous Thromboembolism after Total Knee Arthroplasty in Patients with Rheumatoid Arthritis

Association of Past Smoking Status With Gout in Māori People in Aotearoa New Zealand

Association of Past Smoking Status With Gout in Māori People in Aotearoa New Zealand

Radiographic Axial Spondyloarthritis (Ankylosing Spondylitis) Commencing Late in Life

Broadening the Landscape for Treatment Recommendations in the Management of Axial Spondyloarthritis

Patient profiles in randomised controlled trials versus a real-world study, in psoriatic arthritis: scoping review and meta-analysis.

Pursuing Gender Equity in Rheumatology: Thinking Beyond Gender Representation to Assess Gender Equality